Email this article 
The Parkinson’s disease (PD) pathology is not limited by degeneration of the nigrostriatal dopaminergic system, but includes also wide involvement of different regions of cerebral cortex. The aim of this study was the identification of differences in the brain cortical thickness in patients with early and advanced PD with the use of MRI morphometry. Sixty seven PD patients with Hoehn-Yahr 2 and 3 stages were examined. All patients underwent MRI with subsequent post-processing and receiving of cortical thickness parameters in different brain regions. Significant differences in the visual cortex, the cingulated and fusiform gyri and the frontopolar zone of a dominant hemisphere, and the Brodmann’s areas 1, 2, 3 and 4 of a non-dominant hemisphere were obtained. These data allow revealing relationships between non-motor manifestations of PD and degeneration of certain cortical regions of the brain.
Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo
- Authors: Trufanov A.G.1, Litvinenko I.V.1, Odinak M.M.1, Voronkov L.V.2, Khaimov D.A.2, Efimzev A.Y.2, Fokin V.A.2
-
Affiliations:
- S.M. Kirov Military Medical Academy
- Military Medical Academy named after S.M. Kirov
- Issue: Vol 7, No 3 (2013)
- Pages: 37-41
- Section: Original articles
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/228
- DOI: https://doi.org/10.17816/psaic228
- ID: 228
Cite item
Full Text
Abstract
Keywords
About the authors
Artem G. Trufanov
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: trufanovart@gmail.com
Russian Federation, St. Petersburg
Igor V. Litvinenko
S.M. Kirov Military Medical Academy
Email: trufanovart@gmail.com
Russian Federation, St. Petersburg
Miroslav M. Odinak
S.M. Kirov Military Medical Academy
Email: trufanovart@gmail.com
Russian Federation, St. Petersburg
L. V. Voronkov
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg
D. A. Khaimov
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg
A. Yu. Efimzev
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg
V. A. Fokin
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
Russian Federation, St.-Petersburg
References
- Баранова Т.С., Иллариошкин С.Н. Когнитивные нарушения при болезни Паркинсона: возможности их диагностики с помощью воксел-ориентированной морфометрии. Неврол. вестник 2011; 3: 62–68.
- Баранова Т.С., Коновалов Р.Н., Юдина Е.Н., Иллариошкин С.Н. Воксел-ориентированная морфометрия: новый метод прижизненного мониторинга нейродегенеративного процесса. В сб.: Материалы Всерос. конф. с международным участием «Современные направления исследований функциональной межполушарной асимметрии и пластичности мозга» 2010: 540–543.
- Левин О.С., Федорова Н.В., Шток В.Н. Дифференциальная диагностика паркинсонизма. Журн. неврол. и психиатрии им. С.С. Корсакова 2003; 2: 54–60.
- Литвиненко И.В. Болезнь Паркинсона. М.: Миклош, 2006.
- Ashburner J., Friston K.J. Voxel-based morphometry – the methods. NeuroImage 2000; 11: 805–821.
- Hughes A.J., Daniel S.E., Kilford L., Lees A.J. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. A clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 1992; 55: 181–184.
- Jubault T., Gagnon J.F., Karama S. et al. Patterns of cortical thickness and surface area in early Parkinson’s disease. Neuroimage 2011; 55: 462–467.
- Lyoo C.H., Ryu Y.H., Lee M.S.J. Topographical distribution of cerebral cortical thinning in patients with mild Parkinson’s disease without dementia. Mov. Disord. 2010; 25: 496–499.
- Lyoo C.H., Ryu Y.H., Lee M.S.J. Cerebral cortical areas in which thickness correlates with severity of motor deficits of Parkinson’s disease. J. Neurol. 2011; 258: 1871–1876.
- Niskanen E., Könönen M, Määttä S. et al. New insights into Alzheimer’s disease progression: a combined TMS and structural MRI study. PLoS One 2011; 6: e26113.
- Tinaz S., Courtney M.G., Stern C.E. Focal cortical and subcortical atrophy in early Parkinson’s disease. Mov. Disord. 2011; 26: 436–441.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).