Visualization of dopaminergic midbrain structures in Parkinson’s disease

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Abstract

MRI morphometry of the substantia nigra (SN) and the red nucleus was performed in patients with Parkinson’s disease (PD) (1 and 3 stage by Hoehn and Yahr) and healthy individuals using modes T2 and T2*-WI on magnetic resonance system ”Initial Achieva 3.0T”. Nonsignificant volume decrease of SN was revealed in patients with early manifestations of PD, and vice versa, its increase in symptomatic PD, which can be regarded as an analogue of the well-known phenomenon of ultrasonography in PD. Significantly greater than in the control SN volume asymmetry was marked in PD patients, and asymmetry increased in the progression of the disease. The findings suggest the possibility of using MRI morphometry of the brainstem structures to assess the course of the neurodegenerative process in PD.

 
 

About the authors

R. R. Bogdanov

Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky

Email: kotovsv@yandex.ru
Russian Federation, Moscow

E. I. Manannikova

Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky

Email: kotovsv@yandex.ru
Russian Federation, Moscow

A. S. Abramenko

Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky

Email: kotovsv@yandex.ru
Russian Federation, Moscow

T. V. Maratkanova

Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky

Email: kotovsv@yandex.ru
Russian Federation, Moscow

S. V. Kotov

Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky

Author for correspondence.
Email: kotovsv@yandex.ru
Russian Federation, Moscow

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Copyright (c) 2013 Bogdanov R.R., Manannikova E.I., Abramenko A.S., Maratkanova T.V., Kotov S.V.

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