Нарушения сна и бодрствования при сосудистых когнитивных расстройствах

Tatyana B. Merkulova1, Gennadiy V. Kovrov1, Nikolay N. Yakhno1
1ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» (Сеченовский Университет), Москва, Россия

Аннотация


Деменция — инвалидизирующая патология, которая значительно влияет на качество жизни пациентов и их родственников. Изучение и разработка методов лечения деменции является одним из приоритетных вопросов медицины с учетом темпов роста числа больных. Сосудистая деменция находится на 2-м месте в мире по распространенности после болезни Альцгеймера. Распространенный симптом нейропсихиатрических проявлений деменции — низкое качество сна. Нарушения сна — один из модифицируемых и значимых факторов риска сердечно-сосудистых расстройств, в частности, сосудистых когнитивных нарушений. У пациентов с сосудистой деменцией ряд расстройств сна выражен больше, чем у пациентов с деменцией при болезни Альцгеймера.

В обзоре собраны данные об изменениях цикла сон–бодрствование, которые часто встречаются при сосудистых когнитивных нарушениях. Описаны вероятные механизмы связи нарушений сна и сосудистых когнитивных расстройств. Показана возможность прогнозирования развития сосудистых когнитивных расстройств по выявленным нарушениям сна и отражена перспективность изучения и разработки методов лечения расстройств сна для предупреждения развития сосудистых когнитивных расстройств.

 

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Ключевые слова

сосудистые когнитивные расстройства; нарушения сна и бодрствования; деменция; болезнь Альцгеймера; апноэ

Полный текст:

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Литература

Global action plan on the public health response to dementia 2017–2025. Geneva: World Health Organization; 2017. 52 p

Rizzi L., Rosset I., Roriz-Cruz M. Global epidemiology of dementia: Alzheimer ’ s and vascular types. Biomed Res Int 2014; 2014:908915. DOI: 10.1155/2014/908915. PMID: 25089278

Poluektov M., Preobrazhenskaya I. [Sleep and cognitive dysfunctions. Therapeutic approach]. Nevrologiya, neyropsikhiatriya, psikhosomatika 2014; 6(1): 68–73. DOI: 10.14412/2074-2711-2014-1-68-73. (In Russ.)

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Harris Y., Gorelick P.B., Cohen D. et al. Psychiatric symptoms in dementia associated with stroke: a case-control analysis among predominantly African-American patients. J Natl Med Assoc 1994; 86: 697–702. PMID: 7966434.

Bandyopadhyay T.K., Biswas A., Roy A. et al. Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia. Ann Indian Acad Neurol 2014; 17: 325–330. DOI: 10.4103/0972-2327.138520. PMID: 25221405.

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Mooe T., Rabben T., Wiklund U. et al. Sleep-disordered breathing in men with coronary artery disease. Chest 1996; 109: 659–663. DOI: 10.1378/chest.109.3.659. PMID: 8617073.

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Mohsenin V. Obstructive sleep apnea and hypertension: a critical review. Curr Hypertens Rep 2014; 16: 482. DOI: 10.1007/s11906-014-0482-4. PMID: 25139780.

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Incalzi R.A., Marra C., Salvigni B.L. et al. Does cognitive dysfunction conform to a distinctive pattern in obstructive sleep apnea syndrome? J Sleep Res 2014; 13: 79–86. DOI: 10.1111/j.1365-2869.2004.00389.x. PMID: 14996039.

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Zhu M.F., Deng L.Y., Gong L.M. et al. Macrostructure of sleep in patients with vascular cognitive impairment-no dementia. Nan Fang Yi Ke Da Xue Xue Bao 2011; 31: 295–298. PMID: 21354915.

Tsuno N., Shigeta M., Hyoki K. et al. Fluctuations of source locations of EEG activity during transition from alertness to sleep in Alzheimer’s disease and vascular dementia. Neuropsychobiology 2004; 50: 267–272. DOI: 10.1159/000079982. PMID: 15365227.

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Chappell D.C., Varner S.E., Nerem R.M. et al. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res 1998; 82: 532–539. DOI: 10.1161/01.res.82.5.532. PMID: 9529157.

Boulos M.I., Murray B.J., Muir R.T. et al. Periodic limb movements and white matter hyperintensities in first-ever minor stroke or high-risk transient ischemic attack. Sleep 2016; 40: zsw080. DOI: 10.1093/sleep/zsw080. PMID: 28329254.

Zhong G., Naismith S.L., Rogers N.L., Lewis S.J.G. Sleep-wake disturbances in common neurodegenerative diseases: a closer look at selected aspects of the neural circuitry. J Neurol Sci 2011; 307: 9–14. DOI: 10.1016/j.jns.2011.04.020. PMID: 21570695.

Zhang J., Zhu Y., Zhan G. et al. Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons. J Neurosci 2014; 34: 4418–4431. DOI: 10.1523/jneurosci.5025-12.2014. PMID: 24647961.

Rey N. L., Jardanhazi-Kurutz D., Terwel D. et al. Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice. Neurobiol Aging 2012; 33; 426.e1–426.e11. DOI: 10.1016/j.neurobiolaging.2010.10.009. PMID: 21109328.

Sterniczuk R., Dyck R.H., LaFerla F.M., Antle M.C. Characterization of the 3xTg-AD mouse model of Alzheimer’s disease: Part 1. Circadian changes. Brain Res 2010; 1348: 139–148. DOI: 10.1016/j.brainres.2010.05.013. PMID: 20471965.

Kroeger D., Ferrari L.L., Petit G. et al. Cholinergic, glutamatergic, and GABAergic neurons of the pedunculopontine tegmental nucleus have distinct effects on sleep/wake behavior in mice. J Neurosci 2017; 37: 1352–1366. DOI: 10.1523/jneurosci.1405-16.2016. PMID: 28039375.

Wisor J.P., Edgar D.M., Yesavage J. et al. Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission. Neuroscience 2005; 131: 375–385. DOI: 10.1016/j.neuroscience.2004.11.018. PMID: 15708480.

Javaheri S., Redline S. Insomnia and risk of cardiovascular disease. Chest 2017; 152: 435–444. DOI: 10.1016/j.chest.2017.01.026. PMID: 28153671.

Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 2006; 83: 456S–460S. DOI: 10.1093/ajcn/83.2.456s. PMID: 16470012.

Shearer W.T., Reuben J.M., Mullington J.M. et al. Soluble TNF-α receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol 2001; 107: 165–170. DOI: 10.1067/mai.2001.112270. PMID: 11150007.

Sauvet F., Drogou C., Bougard C. et al. Vascular response to 1week of sleep restriction in healthy subjects. A metabolic response? Int J Cardiol 2015; 190: 246–255. DOI: 10.1016/j.ijcard.2015.04.119. PMID: 25932797.

Münzel T., Camici G.G., Maack C. et al. Impact of oxidative stress on the heart and vasculature. J Am Coll Cardiol 2017; 70: 212–229. DOI: 10.1016/j.jacc.2017.05.035. PMID: 28683969.

Duffy S.L., Lagopoulos J., Terpening Z. et al. Association of anterior cingulate glutathione with sleep apnea in older adults at-risk for dementia. Sleep 2016; 39: 899–906. DOI: 10.5665/sleep.5650. PMID: 26856906.

Nikolenko V.N., Oganesyan M.V., Yakhno N.N. et al. [The brain’s glymphatic system: physiological anatomy and clinical perspectives]. Nevrologiya, neyropsikhiatriya, psikhosomatika 2018; 10(4): 94–100. DOI: 10.14412/2074-2711-2018-4-94-100. (In Russ.)

Jessen N.A., Munk A.S.F., Lundgaard I., Nedergaard M. The glymphatic system: a beginner’s guide. Neurochem Res 2015; 40: 2583–2599. DOI: 10.1007/s11064-015-1581-6. PMID: 25947369.

Beaulieu-Bonneau S., Hudon C. Sleep disturbances in older adults with mild cognitive impairment. Int Psychogeriatr 2009; 21: 654–666. DOI: 10.1017/s1041610209009120. PMID: 19426575.




DOI: http://dx.doi.org/10.25692/ACEN.2020.2.10