Venous thrombogenesis and functional state of the hemorheology and hemostasis system in stroke patients

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Abstract

Comparison of the results of investigation of the hemorheology and hemostasis system in patients with stroke of various types, localization, and severity who were treated at critical and intensive care units, with venous thromboembolic complications (VTECs) and without VTEC, demonstrated a high significance of impairments in the hemorheology and hemostasis system for VTEC pathogenesis in stroke patients. Despite ongoing anticoagulant therapy, aggravation of the prothrombogenic state was observed in VTEC patients. Ischemic stroke was associated with more severe changes compared to hemorrhagic stroke. Hemostasiological predictors of VTEC were identified. In patients without VTEC, both the coagulation and anticoagulation systems as well as the fibrinolysis system were preserved. The D-dimer and thrombophilia markers, such as hyperhomocysteinemia and antiphospholipid syndrome, were shown not to contribute to the development of VTEC in stroke patients.

About the authors

Yulia V. Ryabinkina

Research Center of Neurology

Author for correspondence.
Email: ryabinkina11@mail.ru
ORCID iD: 0000-0001-8576-9983

D. Sci. (Med.), Head, Intensive critical care department

Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80

Mikhail A. Piradov

Research Center of Neurology

Email: ryabinkina11@mail.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

Russian Federation, Moscow

Marine M. Tanashyan

Research Center of Neurology

Email: ryabinkina11@mail.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

Alla A. Shabalina

Research Center of Neurology

Email: ryabinkina11@mail.ru
ORCID iD: 0000-0001-9604-7775

D. Sci. (Med.), leading researcher, Head, Laboratory of hemorheology, hemostasis and pharmacokinetics (with clinical laboratory diagnostics)

Russian Federation, Moscow

M. V. Kostyreva

Research Center of Neurology

Email: ryabinkina11@mail.ru
Russian Federation, Moscow

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Copyright (c) 2016 Ryabinkina Y.V., Piradov M.A., Tanashyan M.M., Shabalina A.A., Kostyreva M.V.

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