Biomarkers of cerebral atherosclerosis: the capabilities of early diagnosis and prognosis of individual risk

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Abstract

The article discusses the results of a study of asymptomatic patients with a severe stenosing process in the brachiocephalic arteries (in a model of carotid atherosclerosis), with emphasis on determination of biochemical markers associated with various stages of atherogenesis. The definition of a group of proatherogenic and atheroprotective biomarkers is suggested and substantiated. Correlations among biomarkers are described. The correlations have potential etiopathogenetic nature, which necessitates further validation of these pathological changes in wider groups of patients.

About the authors

Marine M. Tanashyan

Research Center of Neurology

Email: rasckey@live.com
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

Anton A. Raskurazhev

Research Center of Neurology

Email: rasckey@live.com
ORCID iD: 0000-0003-0522-767X

Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department

Russian Federation, Moscow

Alla A. Shabalina

Research Center of Neurology

Email: rasckey@live.com
ORCID iD: 0000-0001-9604-7775

D. Sci. (Med.), leading researcher, Head, Laboratory of hemorheology, hemostasis and pharmacokinetics (with clinical laboratory diagnostics)

Russian Federation, Moscow

Olga V. Lagoda

Research Center of Neurology

Email: rasckey@live.com
Russian Federation, Moscow

Elena V. Gnedovskaya

Research Center of Neurology

Author for correspondence.
Email: rasckey@live.com
Russian Federation, Moscow

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Copyright (c) 2015 Tanashyan M.M., Raskurazhev A.A., Shabalina A.A., Lagoda O.V., Gnedovskaya E.V.

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