Роль нейрон-астроглиальных взаимодействий в дизрегуляции энергетического метаболизма при ишемическом перинатальном поражении головного мозга

A. B. Salmina1, S. O. Okuneva1, T. E. Taranushenko1, A. A. Fursov1, S. V. Prokopenko1, S. V. Mikhutkina1, N. A. Malinovskaya1, G. A. Tagaeva1
1Красноярская государственная медицинская академия, Россия

Аннотация


Представлен обзор литературы по проблеме гипоксически-ишемического перинатального поражения головного мозга с позиции нарушения астро-глиальной регуляции энергетического метаболизма нейронов и механизмов эксайтотоксичности. Детально обсуждаются особенности энергетического обмена в развивающемся мозге, обусловливающие специфику его поражения в перинатальном периоде, а также клеточно-молекулярные механизмы нарушения нейрон-астроглиальных взаимоотношений, контролирующих регуляцию нейропластичности.

Ключевые слова

нейрон; астроцит; перинатальное гипоксически-ишемическое поражение; головной мозг; энергетический обмен; нейропластичность

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