Congenital pathological tortuosity of the internal carotid artery: population screening and genetic aspects

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Abstract

In the present work results of screening of different variants of pathological tortuosity of internal carotids in a general children population and in a selected group of children suffering from migraine and migraine-like headache are presented. High prevalence of pathological tortuosity of internal carotids, including hemodynamically significant variants of tortuosity in both investigated groups, is noted. Data of clinical, morphological, genealogical and genetic investigations confirmed hereditary determinancy of pathological carotid tortuosity and its interrelation with hereditary syndromal pathology of connective tissue.

About the authors

M. A. Lobov

Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky

Email: sni@neurology.ru
Russian Federation, Moscow

P. O. Kаzаnchyan

MONIKI named after M.V. Vladimirov

Email: sni@neurology.ru
Russian Federation, Moscow

Sergey N. Illarioshkin

Research Center of Neurology

Author for correspondence.
Email: sni@neurology.ru
ORCID iD: 0000-0002-2704-6282

D. Sci. (Med.), Prof., RAS Full Member, Deputy Director for Science; Director, Brain Institute

Russian Federation, 125367, Moscow, Volokolamskoye shosse, 80

Andrey O. Chechetkin

Research Center of Neurology

Email: sni@neurology.ru
ORCID iD: 0000-0002-8726-8928

D. Sci. (Med.), Head, Ultrasound diagnostic laboratory

Russian Federation, Moscow

E. A. Valikov

MONIKI named after M.V. Vladimirov

Email: sni@neurology.ru
Russian Federation, Moscow

O. P. Sidorova

MONIKI named after M.V. Vladimirov

Email: sni@neurology.ru
Russian Federation, Moscow

T. Yu. Tarаkаnоvа

MONIKI named after M.V. Vladimirov

Email: sni@neurology.ru
Russian Federation, Moscow

M. A. Lotareva

MONIKI named after M.V. Vladimirov

Email: sni@neurology.ru
Russian Federation, Moscow

M. N. Borisova

MONIKI named after M.V. Vladimirov

Email: sni@neurology.ru
Russian Federation, Moscow

References

  1. Деев А.С., Захарушкина И.В. Журн. неврол. и психиатрии им. С.С. Корсакова 2000; 1: 14–17.
  2. Казанчян П.О., Валиков Е.А. Патологические деформации внутренних сонных и позвоночных артерий. М.: Медицина, 2005.
  3. Лобов М.А. Ишемические поражения мозга при врожденных аномалиях пре- и церебральных сосудов. В сб.: Материалы Всероссийского симпозиума «Патология сосудов головы и шеи у детей и у подростков». М., 2003: 36–37.
  4. Лелюк В.Г., Лелюк С.Э. Основные принципы гемодинамики и ультразвукового исследования сосудов. Ультразвуковая диагностика патологии магистральных артерий головы. Транскраниальное дуплексное сканирование. В кн.: Руководство по ультразвуковой диагностике. Москва, 1997.
  5. Математические методы в изучении генетики мультифакториальных заболеваний. В кн.: Учебно-методическое пособие для студентов вузов и врачей. М., 1994: 80–106.
  6. Мацкевичус З.К., Паулюкас П.А. Морфологические изменения стенки сонных и позвоночных артерий при их патологических перегибах и петлях. Арх. патол. 1990; 10: 53–58.
  7. Нарычева И.А., Ронкин Я.А., Соколина Н.А. и др. Неврологические проявления синдрома Элерса–Данло. Журн. неврол. и психиатрии им. С.С. Корсакова 1989; 10: 48–53.
  8. Трошин В.М., Бурцев Е.М., Трошин В.Д. Ангионеврология детского возраста. Руководство для врачей. Нижний Новгород, 1995.
  9. Abdul Wahab A., Janahi I.A. A new type of Ehrlers–Danlos syndrome associated with tortuous systemic arteries in a large kindred from Qatar. Arch. Paediatr 2003; 92: 456–462.
  10. Askalan R., Laughlin S., Mayank S. et al. Chickenpox and stroke in childhood: a study of frequency and causation. Stroke 2001; 32: 1257–1262.
  11. Beighton P. The Ehlers–Danlos syndromes in heritable disorders of connective tissue. St. Louis: Mosby, 1993: 189–250.
  12. Bojinova V., Dimova P., Belopitova L. Clinical manifestation of cerebrovascular hipoplasias in childhood. J. Child. Neurol. 2000; 15: 166–171.
  13. Croisile B., Deruty R. et al. Aneurysm of the internal carotid artery and cervical mega-dolicho-arteries in Marfan syndrome. Neurochirurgie 1988; 34: 342–347.
  14. de Veber G. Stroke and the child’s brain: an overview of epidemiology, syndromes and risk factors. Curr. Opin. Neurol. 2002; 15: 133–138.
  15. de Veber G., Chan A., Monagle P. et al. Anticoagulation therapy in pediatric patients with sinovenous thrombosis: a cohort study. Neurology 1998; 51: 1622–1688.
  16. Dobrin P.B., Mrkvicka R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation. Cardiovasc. Surg. 1994; 2: 484–448.
  17. Fisher R.G. Stroke in children. Their relationship to intrinsic pathology of the carotid artery. Am. Surg. 1982; 48: 344–350.
  18. Gardella R., Zoppi N., Assanelli D. et al. Exclusion of candidate genes in a family with arterial tortusity syndrome. Am. J. Med. Genet. 2004; 30: 221–228.
  19. Giroud M., Lemesle M., Madinier G., Manceau E. et al. Stroke in children under 16 years of age, сlinical and etiological difference with adults. Arch. Neurol. Scand. 1997; 96: 401–406.
  20. Huemer M., Emminger W. Kinking and stenosis of the carotid artery associated with homolateral ischaemic brain infarction in a patient treated with cyclosporine A. Eur. J. Pediatr. 1998; 157: 599–601.
  21. Keidan I., Shahar E., Barzilay Z., Passwell J., Brand N. Predictor of outcome of stroke in infants and children based on clinical data and radiologic correlates. Arch. Paediatr. 1994; 83: 762–765.
  22. Kirkham F.J., Prengler M., Hewes D.K., Ganesan V. Risk factors for arterial ischemic stroke in children. J. Child. Neurol. 2000; 15: 299–307.
  23. Kittner S.J., Adams R.J. Stroke in children and young adults. Curr. Opin. Neurol. 1996; 9: 53–56.
  24. Kramarow E., Lentzner H. Health and Aging Chartbook US, 1999. Hyattsville, National Centre for Health Statistics, 1999.
  25. Menovsky T., van Overbeeke J.J. Cerebral arteriovenous malformations in childhood: state of the art with special reference to treatment. Eur. J. Pediatr. 1997; 156: 741–746.
  26. Pascual-Castroviejo I., Viafio J., Moreno F. et al. Hemangiomas of the head, neck, and chest with associated vascular and brain anomalies: A complex neurocutaneous syndrome. Am. J. Neuroradiol. 1997; 17: 461–467.
  27. Shievink W.I., Limburg M., Oorthuys J.W. et al. Cerebrovascular disease in Ehlers-Danlos type IV. Stroke 1990; 21: 626–632.

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Copyright (c) 2007 Lobov M.A., Kаzаnchyan P.O., Illarioshkin S.N., Chechetkin A.O., Valikov E.A., Sidorova O.P., Tarаkаnоvа T.Y., Lotareva M.A., Borisova M.N.

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