Невропатия тонких волокон

N. A. Suponeva1, N. V. Belova1, N. I. Zaitseva2, D. G. Yusupova1, D. Yu. Lagoda1, O. S. Korepina1, M. A. Piradov1
1ФГБНУ «Научный центр неврологии», Москва, Россия; 2ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Россия

Аннотация


Невропатия тонких волокон (НТВ), несмотря на тридцатилетнюю историю изучения, остается одним из самых загадочных заболеваний, которые с трудом поддаются диагностике и лечению. Распространенность НТВ составляет 52,95 на 100 000 населения, наиболее частой причиной ее развития считается сахарный диабет. В результате повреждения тонких миелинизированных Аδ- и немиелинизированных С-волокон формируются хронический невропатический болевой синдром, расстройства температурной чувствительности, вегетативные нарушения. Заболевание в основном развивается по «восходящему типу», распространяясь со стоп на проксимальные отделы и руки, тип поражения нервов – первично аксональный. Несмотря на то, что НТВ считается одной из самых «доброкачественных» невропатий, т.к. не вовлекает крупные чувствительные и двигательные волокна, качество жизни пациентов заметно снижается.


Ключевые слова

невропатия тонких волокон (НТВ); дистальная невропатия; проксимальная невропатия; каналопатия; биоп- сия кожи; количественное чувствительное тестирование (КЧТ); количественное тестирование судомоторного аксон-рефлекса (КСАР)

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Литература

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DOI: http://dx.doi.org/10.18454/ACEN.2017.1.6169