Neuroprotection in cerebrovascular diseases: is it the search for life on Mars or a promising trend of treatment? Part 1. Acute stroke

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Abstract

The two key strategies of specific treatment of stroke are reperfusion, aimed on the improvement of brain perfusion in the ischemic region due to the restoration of blood flow and prevention of recurrent thrombosis, and neuroprotection to maintain brain tissue metabolism and to protect it from structural damage. The evidential base of major neuroprotective drugs (nimodipine, magnesium sulfate, piracetam, ethylmethylhydroxypyridine succinate, choline alfoscerate, cerebrolysin, albumin, citicoline, edaravone) and hypothermia use in acute stroke setting is critically reviewed in the article.

 

About the authors

Mikhail A. Piradov

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

Russian Federation, Moscow

Marine M. Tanashyan

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

M. A. Domashenko

Research Center of Neurology

Email: ncnmaximova@mail.ru
Russian Federation, Moscow

Dmitry V. Sergeev

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-9130-1292

Cand. Sci. (Med.), neurologist, Neurorehabilitation department with TMS group

Russian Federation, 125367, Russia, Moscow, Volokolamskoye shosse, 80

Marina Yu. Maksimova

Research Center of Neurology

Author for correspondence.
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-7682-6672

D. Sci. (Med), Prof., Head, 2nd Neurology department

Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80; Moscow

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