Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental Neurology2075-54732409-2533Research Center of Neurology18210.17816/psaic182UnknownNeurological debut of non-Hodgkin’s lymphoma: the complexity of diagnosisMagzhanovR. V.bsmu-neuro@yandex.ruBakhtiyarovaK. Z.bsmu-neuro@yandex.ruTunikV. F.bsmu-neuro@yandex.ruDolganyukV. K.bsmu-neuro@yandex.ruGalliamovaN. A.bsmu-neuro@yandex.ruZakirovaE. N.bsmu-neuro@yandex.ruPervushinaE. V.bsmu-neuro@yandex.ruBashkir State Medical UniversityG.G. Kuvatov Republican Clinical Hospital0906201482374001022017Copyright © 2014, Magzhanov R.V., Bakhtiyarova K.Z., Tunik V.F., Dolganyuk V.K., Galliamova N.A., Zakirova E.N., Pervushina E.V.2014<p>A rare case of system non-Hodgkins lymphoma manifested withoculomotor abnormalities is presented in the paper. In the patientexamined, initial symptoms were diplopia and restriction of thelateral eye movements; these symptoms appeared on the backgroundof the intense headaches. The death resulted from the acutecardio-pulmonary failure. On postmortem study, B-cell lymphomaof multiple localizations, including the central nervous system,heart, lymph nodes, spleen and liver, was found.</p>non-Hodgkin's lymphomadiplopiamultisystem manifestationsнеходжкинская лимфомадиплопиямультисистемные проявления[Гематология: руководство для врачей (под ред. Н.Н. Мамаева, С.И. Рябова). СПб.: СпецЛит, 2008.][Гончарова О.В., Липатов О.Н. Оценка распространенности неходжкинских лимфом. Мед. Вестн. Башкортостана 2009; 1: 25–28.][Akaza M., Tsunemi T., Sanjo N. et al. Malignant lymphoma presented as left trigeminal neuralgia. Rinsho Shinkeigaku 2009; 49: 432–436.][Arai A., Taomoto K., Yokoyama M. et al. A case of CNS metastasis from gastric MALT lymphoma. No Shinkei Geka 2009; 37: 1235–1240.][Hunt K.E., Reichard K.K. Diffuse large B-cell lymphoma. Arch. Pathol. Lab. Med. 2008; 132; 118–124.][Kawano N., Ochiai H., Yoshida S. et al. Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture. Int. J. Clin. Oncol. 2012; 17: 336–340.][Kobayashi Z., Tsuchiya K., Machida A. et al. Metastatic CNS lymphoma presenting with periventricular dissemination – MRI and neuropathological findings in an autopsy case. J. Neurol. Sci. 2009; 277:109–113.][Miranda R.N., Glantz L.K., Myint M.A. et al. Stage IE non-Hodgkin’s lymphoma involving the dura: A clinicopathologic study of five cases. Arch. Pathol. Lab. Med. 1996; 120: 254–260.][Muzaffar S., Siddiqui M.S., Siddiqui I. et al. Central nervous system lymphomas: a histologic and immunophenotypic analysis. J. Pak. Med.Assoc. 2000; 50: 141–144.][Ono K., Arimoto H., Wada K. et al.Multicentric involvement of non-Hodgkin’s lymphoma in the central nervous system and testis-case report. Neurol. Med. Chir. 2004; 44: 493–496.][Sumrall A, Herrin V. Recurrent, transformed non-Hodgkin’s lymphoma presenting as chiasmal syndrome with hyperprolactinemia and hypopituitarism. J. Miss. State Med. Assoc. 2010; 51: 35–36.]