Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental Neurology2075-54732409-2533Research Center of Neurology24110.17816/psaic241UnknownRobot-assisted therapy with the use of MOTOmed letto 2 in complex early rehabilitation of patients with stroke admitted to the intensive care unitProkazovaPolina R.<p>Cand. Sci. (Med.), neurologist, Intensive critical care department</p>polinaprokazova@gmail.comhttps://orcid.org/0000-0001-5837-6391PiradovMikhail A.<p>D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director</p>polinaprokazova@gmail.comhttps://orcid.org/0000-0002-6338-0392RyabinkinaYulia V.<p>D. Sci. (Med.), Head, Intensive critical care department</p>polinaprokazova@gmail.comhttps://orcid.org/0000-0001-8576-9983KunzevichG. I.polinaprokazova@gmail.comGnedovskayaElena V.polinaprokazova@gmail.comPopovaL. A.polinaprokazova@gmail.comResearch Center of Neurology0906201372111502022017Copyright © 2013, Prokazova P.R., Piradov M.A., Ryabinkina Y.V., Kunzevich G.I., Gnedovskaya E.V., Popova L.A.2013<p>Objective: to assess the effect of early robot-assisted rehabilitation(MOTOmed Letto 2) on neurological recovery, severity of the disease,the rate and severity of multiple organ dysfunction syndromeand the rate of venous thromboembolism in acute stroke patientsduring intensive care unit (ICU) stay, including patients whorequire mechanical ventilation. This case-control study included66 patients (49 males and 17 females, median age 59) with acuteischemic stroke and cerebral hemorrhage admitted to ICU.Patients were distributed into two comparable groups, intervention(n=33) and control group (n=33), and monitored fromadmission to day 21. Both groups received standard rehabilitationfrom admission, and patients in the intervention group alsoreceived robot-assisted arm and leg therapy. Groups had similarmedian GCS, NIHSS, APACHE II, MODS scores on admission.There was no significant difference in neurological and medicaloutcome on day 21 (median GCS: 15 vs. 15, p=0.32; medianNIHSS 11 vs. 15, p0.05; median APACHE II 6 vs. 9, p 0.05;median MODS 0 vs. 1, p 0.05 in the intervention and controlgroup, respectively). The rate of multiple organ dysfunction syndromeand deep venous thrombosis (DVT) on day 21 was alsosimilar in the intervention and control groups (60% vs. 67%,p0.05, and 57.6% vs. 45.4%, p0.05, respectively). The rate ofsevere multiple organ dysfunction syndrome, incidence of pulmonicembolism (PE) and mortality rate were lower in the interventiongroup vs. control group (14%, vs. 41%, p0.05; 12% vs.33%; p0.05; 12% vs. 39%, p0.05, respectively). Early robotassistedtherapy in patients with severe stroke admitted to the ICUwas associated with significant reduction of PE rate, incidence ofsevere multiple organ dysfunction syndrome and mortality on day21, but did not influence neurological outcome and DVT rate.</p>strokeearly rehabilitationintensive care unitrobot-assisted therapyинсультранняя реабилитацияотделение реанимации и интенсивной терапиироботизированная механотерапия[Домашенко М.А., Черникова Л.А., Шестакова М.В. и др. Способ профилактики гипостатической пневмонии и тромбоза глубоких вен нижних конечностей у пациентов в остром периоде инсульта. Патент на изобретение № 2448671, 2010.][Кадыков А.С., Черникова Л.А., Шахпаронова Н.В. Н.В. Реабилитация неврологических больных. В кн.: Кадыков А.С., Черникова Л.А., Шахпаронова Н.В. Основные принципы реабилитации больных с заболеваниями головного мозга. М.:МЕДпресс-информ, 2008: 25–34.][Пирадов М.А., Гулевская Т.С., Гнедовская Е.В. и др. 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