Features of atherosclerosis of the cerebral arteries and pathomorphology of cerebral infarctions in patients with type 2 diabetes mellitus

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Abstract

Comparison of the results of 20 autopsy cases of ischemic strokes developed during atherosclerosis with 20 autopsy cases of ischemic strokes associated with atherosclerosis in combination with type 2 diabetes mellitus (T2DM) provided data indicating a high significance of T2DM in the development of severe changes in the cerebral arteries, causing cerebral infarctions of various size and localization. A significant prevalence in the number of atherosclerotic plaques in the cerebral arteries, including those causing stenosis of the lumen by 50% or more, was found in the case of T2DM compared to cases without T2DM. Cerebral infarctions in T2DM were mostly of the multiple nature that was determined by a combination of fresh or organizing extensive, large or medium, infarction with one/several organized medium, small deep, and small surface infarctions. More severe atherosclerosis of the cerebral arteries in T2DM caused a higher rate of infarctions due to occlusive atherothrombosis, arterio-arterial embolism, and tandem atherostenosis in these patients compared to cases without T2DM. In the absence of T2DM, infarctions occurred more often due to embolism of the cerebral arteries from the heart with coronary heart disease compared to cases with T2DM.

About the authors

Pavel L. Anufriev

Research Center of Neurology

Email: anufriev@neurology.ru
ORCID iD: 0000-0002-5327-2275

Cand. Sci. (Med.), senior researcher, Laboratory of neuromorphology

Russian Federation, 125367, Moscow, Volokolamskoye shosse, 80

Marine M. Tanashyan

Research Center of Neurology

Email: anufriev@neurology.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

Tatyana S. Gulevskaya

Research Center of Neurology

Email: anufriev@neurology.ru
ORCID iD: 0000-0003-2970-8136

D. Sci. (Med.), Prof., chief researcher, Laboratory of neuromorphology

Russian Federation, 125367, Moscow, Volokolamskoye shosse, 80

Renat E. Ablyakimov

Research Center of Neurology

Email: anufriev@neurology.ru
Russian Federation, Moscow

Elena V. Gnedovskaya

Research Center of Neurology

Author for correspondence.
Email: anufriev@neurology.ru
Russian Federation, Moscow

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Copyright (c) 2015 Anufriev P.L., Tanashyan M.M., Gulevskaya T.S., Ablyakimov R.E., Gnedovskaya E.V.

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