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Antiparkinsonian effects of dicholine succinate (intranasal application of 0.2–5.0 mg/kg) was studied in the C57Bl/6 mice model of parkinsonism caused by a single i.p. injection of 25 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Dicholine succinate was found to be characterized by significant antiparkinsonian effects, as indicated by reduction of akinesia in the “open field” test horizontal locomotor activity (0.2, 1.0 and 5.0 mg/kg) and reduction of muscle rigidity assessed through the step length (1.0 and 5.0 mg/kg). However, dicholine succinate did not exhibit any effect on such major MPTP-induced parkinsonian symptoms as tremor, piloerection, latero- and retropulsion.
Antiparkinsonian effect of dicholine succinate on the model of MPTP-induced parkinsonism
- Authors: Sariev A.K.1, Rychikhin V.M.1, Pomytkin I.A.2, Voronina T.A.3
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Affiliations:
- Research Center of Neurology, Russian Academy of Medical Sciences
- Biosignal, Ltd
- Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 5, No 4 (2011)
- Pages: 33-36
- Section: Original articles
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/290
- DOI: https://doi.org/10.17816/psaic290
- ID: 290
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About the authors
A. K. Sariev
Research Center of Neurology, Russian Academy of Medical Sciences
Email: platonova@neurology.ru
Russian Federation, Moscow
V. M. Rychikhin
Research Center of Neurology, Russian Academy of Medical Sciences
Email: platonova@neurology.ru
Russian Federation, Moscow
I. A. Pomytkin
Biosignal, Ltd
Email: platonova@neurology.ru
Russian Federation, Moscow
T. A. Voronina
Research Institute of Pharmacology, Russian Academy of Medical Sciences
Author for correspondence.
Email: platonova@neurology.ru
Russian Federation, Moscow
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