Regional pattern of beta-amyloid accumulation in the preclinical and clinical states of Alzheimer’s disease

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Abstract

Amyloid- (A ) plaque accumulation in the brain is a hallmark of Alzheimer’s disease (AD). The concept of preclinical AD implies that A deposits may accumulate in the brain years prior to the clinical manifestations of AD. In this study, we measured binding potentials (BP) of different brain regions using positron emission tomography (PET) study with A radiotracer N-methyl-[11C]2-(4ґ-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) in 16 patients with mild to moderate dementia of Alzheimer’s type (DAT) and 223 cognitively normal individuals aged 50 to 86 years old. Mean cortical BP was calculated from binding potentials of brain regions prone to A accumulation and was used as a measure to define threshold value for abnormal elevation of [11C]PIB uptake in cognitively normal individuals. In both groups, with low (n=181) or high (n = 42) A accumulation, the highest [11C]PIB BP was demonstrated in the precuneus. In DAT patients, A accumulation was substantially increased in all regions, with the precuneus and prefrontal cortex having the highest [11C] PIB BP. We suggest that the precuneus may be brain region with the earliest involvement in the A plaque accumulation.

 
 

About the authors

A. G. Vlassenko

Departments of Radiology and Neurology and the Knight Alzheimer’s Disease Research Center, Washington University School of Medicine

Email: andrei@npg.wustl.edu
United States, St. Louis, MO, USA

J. C. Morris

Departments of Radiology and Neurology and the Knight Alzheimer’s Disease Research Center, Washington University School of Medicine

Email: andrei@npg.wustl.edu
United States, St. Louis

M. A. Minton

Departments of Radiology and Neurology and the Knight Alzheimer’s Disease Research Center, Washington University School of Medicine

Author for correspondence.
Email: andrei@npg.wustl.edu
United States, St. Louis

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Copyright (c) 2010 Vlassenko A.G., Morris J.C., Minton M.A.

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