Neuron-astroglial interactions in dysregulation of energy metabolism in perinatal ischemic brain damage

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Abstract

Presented is a review of the literature on the problem of hypoxic-ischemic perinatal brain damage in the context of alterations of astroglial regulation of neuronal energy metabolism and mechanisms of excitotoxicity. Characteristics of energy metabolism in the developing brain responsible for specificity of its damage in perinatal period, as well as cell and molecular mechanisms of disturbances of neuron-astrocyte coupling controlling regulation of neuroplasticity are discussed.

 
 

About the authors

Alla B. Salmina

Voyno-Yasenetsky Krasnoyarsk State Medical University

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

S. O. Okuneva

Krasnoyarsk State Medical Academy

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

T. E. Taranushenko

Krasnoyarsk State Medical Academy

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

A. A. Fursov

Krasnoyarsk State Medical University

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

Semen V. Prokopenko

Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

S. V. Mikhutkina

Krasnoyarsk State Medical Academy

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

N. A. Malinovskaya

Krasnoyarsk State Medical Academy

Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

G. A. Tagaeva

Krasnoyarsk State Medical Academy

Author for correspondence.
Email: s.v.proc.58@mail.ru
Russian Federation, Krasnoyarsk

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Copyright (c) 2008 Salmina A.B., Okuneva S.O., Taranushenko T.E., Fursov A.A., Prokopenko S.V., Mikhutkina S.V., Malinovskaya N.A., Tagaeva G.A.

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