Кортикальная реорганизация при рассеянном склерозе

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Аннотация

Функциональная магнитно-резонансная томография (фМРТ) является новым методом, способствующим изучению функций мозга и взаимоотношений между физиологической активностью и анатомической локализацией. В настоящее время реорганизация коры рассматривается как один из возможных факторов, обусловливающих улучшение или поддержание функции в случае необратимого повреждения мозга при рассеянном склерозе (РС). Функциональные кортикальные изменения коры были выявлены при всех фенотипах РС с использованием различных парадигм фМРТ, однако наиболее изучена двигательная система. Показана вариабельность функциональной реорганизации двигательной коры при РС в зависимости от стадии болезни. Кортикальная реорганизация играет роль в ограничении влияния структурных повреждений при РС; напротив, нарушение этих пластических механизмов может обусловливать развитие необратимого неврологического дефицита по мере прогрессирования болезни. Дальнейшие фМРТ-исследования в динамике позволят оценить изменения функциональной активности мозга при различной выраженности неврологического дефицита и различном характере регресса симптомов РС. Улучшение кортикальной адаптивной пластичности представляет собой потенциально значимое направление реабилитации больных РС.

Об авторах

И. A. Завалишин

ФГБНУ «Научный центр неврологии»

Email: krotenkova_mrt@mail.ru
Россия, Москва

A. В. Переседова

ФГБНУ «Научный центр неврологии»

Email: krotenkova_mrt@mail.ru
Россия, Москва

Марина Викторовна Кротенкова

ФГБНУ «Научный центр неврологии»

Автор, ответственный за переписку.
Email: krotenkova_mrt@mail.ru
ORCID iD: 0000-0003-3820-4554

д.м.н., зав. отделением лучевой диагностики Института клинической и профилактической неврологии

Россия, Москва

O. В. Пугачева

ФГБНУ «Научный центр неврологии»

Email: krotenkova_mrt@mail.ru
Россия, Москва

Ольга Васильевна Трифонова

ФГБНУ «Научный центр неврологии»

Email: krotenkova_mrt@mail.ru
Россия, Москва

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© Zavalishin I.A., Peresedova A.V., Krotenkova M.V., Pugacheva O.V., Trifonova O.V., 2008

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