Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors

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Abstract

Endogenous cannabinoid system plays an important physiological role in brain functioning, being related to regulation of neuromediator processes and mechanisms of neuroplasticity. Cannabinoid receptors of type 1 (CB1) represent one of the key elements of this system and convenient object for various experimental effects. We showed plastic reorganization of synapses in hippocampal CA1 stratum radiatum in vitro resulted from pharmacological blockade of CB1. The ultrastructural features of this reorganization are the formation of numerous perforated contacts with elongated synaptic membranes of modified configuration, spatial synaptic rearrangement, and the appearance of atypical synaptic connections. The obtained results suggest that involvement of CB1 in modulation of synaptic transmission is one of the mechanisms which ensure the stable morphofunctional state of synapse and promote its integrity in disturbances of neurotransmission regulation.

About the authors

L. E. Frumkina

Research Center of Neurology, Russian Academy of Medical Sciences

Email: khaspekleon@mail.ru
Russian Federation, Moscow

M. Yu. Bobrov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Medical Sciences

Email: khaspekleon@mail.ru
Russian Federation, Moscow

A. A. Lyzhin

Research Center of Neurology

Email: khaspekleon@mail.ru
Russian Federation, Moscow

E. L. Andrianova

Research Center of Neurology

Email: khaspekleon@mail.ru
Russian Federation, Moscow

S. K. Koroleva

Research Center of Neurology

Email: khaspekleon@mail.ru
Russian Federation, Moscow

N. A. Bobrova

Russian State Medical University

Email: khaspekleon@mail.ru
Russian Federation, Moscow

Leonid G. Khaspekov

Research Center of Neurology

Author for correspondence.
Email: khaspekleon@mail.ru
Russian Federation, Moscow

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Copyright (c) 2007 Frumkina L.E., Bobrov M.Y., Lyzhin A.A., Andrianova E.L., Koroleva S.K., Bobrova N.A., Khaspekov L.G.

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