Ишемический инсульт и наследственные тромбофилические состояния
- Авторы: Пизова Н.В.1
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Учреждения:
- ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России
- Выпуск: Том 11, № 4 (2017)
- Страницы: 71-79
- Раздел: Обзоры
- Дата подачи: 24.12.2017
- Дата публикации: 27.12.2017
- URL: https://annaly-nevrologii.com/journal/pathID/article/view/502
- DOI: https://doi.org/10.18454/ACEN.2017.4.8
- ID: 502
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Аннотация
В обзоре представлен детальный анализ роли наиболее распространенных форм тромбофилий в формировании риска ишемического инсульта и атеротромбоза в популяции. Рассмотрено функциональное значение различных генотипов β-фибриногена в их взаимосвязи с ишемическими нарушениями мозгового кровообращения, атеросклеротическим поражением брахиоцефальных артерий, артериальной гипертензией. Представлены ассоциации между развитием инсульта и такими ключевыми генетическими факторами, как Лейденская мутация (фактор V), мутации в генах протромбина, ингибитора активатора плазминогена 1 типа, гликопротеина IIIa и др. Представлены собственные данные, касающиеся распространенности различных вариантов наследственных тромбофилий в группе из 43 пациентов с ишемическим инсультом неуточненного генеза.
Ключевые слова
Об авторах
Наталья Вячеславовна Пизова
ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России
Автор, ответственный за переписку.
Email: pizova@yandex.ru
Россия, Ярославль
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