The main pathogenetic mechanisms of vascular cerebral pathology associated with atherosclerosis and metabolic syndrome: the search for correction approaches

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Abstract

Metabolic syndrome (MS) is a risk factor for the development of acute and chronic vascular diseases of the brain. Oxidative stress developing under these conditions promotes the progression of atherosclerotic disease of the brachiocephalic arteries, which necessitates correction of the identified pathobiochemical abnormalities. The use of antioxidant drugs in patients with cerebrovascular diseases and MS reduces manifestations of the latter, including insulin resistance, hypertriglyceridemia, and hyperglycemia. The article presents the results of investigation of the drug mexidol in patients with chronic cerebrovascular diseases associated with atherosclerosis and MS. The findings demonstrate that drugs of this group have good prospects to be used for comprehensive correction of various pathogenic stages of the developing pathology.

About the authors

Marine M. Tanashyan

Research Center of Neurology

Email: angionev@gmail.com
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

Оlga V. Lagoda

Research Center of Neurology

Author for correspondence.
Email: angionev@gmail.com
ORCID iD: 0000-0001-7562-4991

Cand. Sci. (Med.), senior researcher, 1st Neurological department

Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80

Kseniya V. Antonova

Research Center of Neurology

Email: angionev@gmail.com
ORCID iD: 0000-0003-2373-2231

D. Sci. (Med.), leading researcher, 1st Neurological department

Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80

Anton A. Raskurazhev

Research Center of Neurology

Email: angionev@gmail.com
Russian Federation, Moscow

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Copyright (c) 2016 Tanashyan M.M., Lagoda O.V., Antonova K.V., Raskurazhev A.A.

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