Механизмы нейрогенеза и ангиогенеза при ишемическом инсульте: обзор литературы

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Научные достижения последних десятилетий свидетельствуют о том, что нейрогенез и ангиогенез являются взаимосвязанными процессами в борьбе за функциональное восстановление после ишемического инсульта головного мозга. В обзоре литературы приведены современные данные о нейрососудистых взаимодействиях при ишемическом инсульте, описана роль сигнальных молекул и факторов роста в регуляции нейрогенеза и ангиогенеза, имеющих решающее значение в нейронном выживании и нейропластичности. Авторами проведён поиск литературы об атипичной миграции нейробластов в зону ишемической полутени и роли сигнальных молекул, о молекулярных мишенях ангиогенеза, роли эндогенных факторов роста и нейрохимических маркёрах регуляции постинсультной сосудистой активности при острой ишемии головного мозга с использованием соответствующих ключевых слов в поисковых системах PubMed и Google Scholar, по базам данных Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, eLibrary и др.

Несмотря на многообещающие результаты, полученные на животных моделях, и данные клинических исследований, глубинные взаимосвязи молекулярно-клеточных взаимодействий нейрогенеза и ангиогенеза до конца не ясны. Дальнейшее изучение и понимание сложных взаимодействий нейрогенеза и ангиогенеза целесообразно с точки зрения поиска мишеней для экзогенного введения факторов роста и изменения экспрессии эндогенно продуцируемых молекул для лечения ишемического повреждения головного мозга.

Об авторах

Екатерина Сергеевна Королева

ФГБОУ ВО «Сибирский государственный медицинский университет»

Автор, ответственный за переписку.
Email: kattorina@list.ru
ORCID iD: 0000-0003-1911-166X

к.м.н., доцент каф. неврологии и нейрохирургии

Россия, 634055, Томск, Московский тракт, д. 2

Валентина Михайловна Алифирова

ФГБОУ ВО «Сибирский государственный медицинский университет»

Email: v_alifirova@mail.ru
ORCID iD: 0000-0002-4140-3223

д.м.н., проф., зав. каф. неврологии и нейрохирургии

Россия, 634055, Томск, Московский тракт, д. 2

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