Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector104710.17816/ACEN.1047ReviewsОбзорыReview ArticleOxytocin and Vasopressin in Emotional Memory and “Face Reading”: a Neurobiological Approach and Clinical AspectsРоль окситоцина и вазопрессина в эмоциональной памяти и «чтении мыслей по лицу»: нейробиологический подход и клинические аспектыhttps://orcid.org/0000-0002-3341-1557GorinaYana V.ГоринаЯна Валерьевна
Russian Federation

Cand. Sci. (Pharm.), Associate Professor, senior researcher, Laboratory of social neurosciences, Associate Professor, Department of biological chemistry with courses medical, pharmaceutical and toxicological chemistry, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Associate Professor, Department of biophysics, Siberian Federal University

канд. фарм. наук, доцент, с. н. с. лаб. социальных нейронаук, доцент каф. биологической химии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. проф. В.Ф. Войно-Ясенецкого; доцент каф. биофизики Сибирского федерального университета

yana_20@bk.ruhttps://orcid.org/0000-0002-7884-2721LopatinaOlga L.ЛопатинаОльга Леонидовна
Russian Federation

Dr. Sci. (Biol.), Associate Professor, Head, Laboratory of social neurosciences, Professor, Department of biological chemistry with courses medical, pharmaceutical and toxicological chemistry, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Professor, Department of biophysics, Siberian Federal University

д-р биол. наук, доцент, рук. лаб. социальных нейронаук, проф. каф. биологической химии с курсами медицинской, фармацевтической и токсикологической химии КрасГМУ им. проф. В.Ф. Войно-Ясенецкого; проф. каф. биофизики Сибирского федерального университета

ol.lopatina@gmail.comhttps://orcid.org/0000-0003-3858-5369MararitsaLarisa V.МарарицаЛариса Валерьевна
Russian Federation

Cand. Sci. PhD (Psychol.), senior researcher, Laboratory of social and cognitive informatics, St. Petersburg School of social sciences and area studies

канд. пcихол. наук, с. н. с. лаб. социальной и когнитивной информатики Санкт-Петербургской школы социальных наук и востоковедения

mararitsalarisa@gmail.comProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityКрасноярский государственный медицинский университет имени профессора В.Ф. Войно-ЯсенецкогоSiberian Federal UniversityСибирский федеральный университетNational Research University "Higher School of Economics"Национальный исследовательский университет «Высшая школа экономики»0310202418358710410202327102023Copyright ©; 2024, Gorina Y.V., Lopatina O.L., Mararitsa L.V.Copyright ©; 2024, Горина Я.В., Лопатина О.Л., Марарица Л.В.2024Gorina Y.V., Lopatina O.L., Mararitsa L.V.Горина Я.В., Лопатина О.Л., Марарица Л.В.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/1047

The ability to adequately perceive and recognize emotions is a key and universal tool in interpersonal communication, which allows people to understand feelings, intentions, and emotional reactions of themselves and others. Throughout their life, people have to make inferences about mental state of others by interpreting subtle social signals, such as facial expressions, to understand or predict others’ behavior, which is crucial in constructive social interactions. Therefore, emotional memory associated with the ability to identify emotions based on one’s life experience is the cornerstone of social cognition and interpersonal relationships. Oxytocin and vasopressin are neurohypophysial peptides that have attracted scientific attention due to their role in the emotional and social aspects of behavior. Variable and contrasting effects of oxytocin and vasopressin may be related to the sites of the brain where they exert their activity.

Aim. This review aimed to evaluate neural mechanisms underlying oxytocin-mediated and vasopressin-mediated modulation of emotional memory; to assess how cerebral oxytocin-signal and vasopressin-signal transduction mediates emotional and social behavior; to discuss the role of the two neuropeptides in non-verbal interpersonal communication; and to present their cerebral effects in relation to an ability for “face reading” in patients with mental disorders.

Способность правильно воспринять и распознать эмоции является ключевым и универсальным инструментом в межличностном общении, который позволяет понять чувства, намерения и эмоциональные реакции — свои и другого человека. На протяжении всей жизни людям приходится делать выводы о психическом состоянии путём интерпретации тонких социальных сигналов, таких как выражение лица, чтобы осознать или предсказать поведение другого человека, что, несомненно, имеет решающее значение в выстраивании конструктивных социальных взаимодействий. В этой связи эмоциональная память, сопряжённая со способностью идентифицировать эмоции, базируясь на приобретённом жизненном опыте, является краеугольным камнем социального познания и межличностных отношений. Окситоцин и вазопрессин — два нейрогипофизарных пептида, которые привлекают внимание учёных за счёт их роли в реализации эмоциональных и социальных аспектов поведения. Установленные разнообразные и контрастирующие эффекты окситоцина и вазопрессина могут быть связаны с местом их активности в головном мозге.

Цель обзора — рассмотреть нейронные механизмы, лежащие в основе окситоцин- и вазопрессин-опосредованной модуляции эмоциональных воспоминаний, как церебральная окситоцин- и вазопрессин-сигнальная трансдукция опосредует эмоциональное и социальное поведение; обсудить роль двух нейропептидов в невербальном межличностном общении, а также представить их церебральные эффекты в отношении способности «чтения мысли по лицу» в контексте развития психоэмоциональных расстройств.

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