Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector106710.17816/ACEN.1067ReviewsОбзорыReview ArticlePrimary Progressive Aphasia: Variants and Main Language DomainsПервичная прогрессирующая афазия: варианты и основные речевые доменыhttps://orcid.org/0000-0001-6491-2891AkhmadullinaDiliara R.АхмадуллинаДиляра Робертовна
Russian Federation

postgraduate student

аспирант

fedotova@neurology.ruhttps://orcid.org/0000-0001-8070-7644FedotovaEkaterina Y.ФедотоваЕкатерина Юрьевна
Russian Federation

Dr. Sci. (Med.), leading researcher, Head, 5th Neurology department, Institute of Clinical and Preventive Neurology

д-р мед. наук, в. н. с., зав. 5-м неврологическим отделением Института клинической и профилактической неврологии

fedotova@neurology.ruResearch Center of NeurologyНаучный центр неврологии0612202418468753011202308122023Copyright ©; 2024, Akhmadullina D.R., Fedotova E.Y.Copyright ©; 2024, Ахмадуллина Д.Р., Федотова Е.Ю.2024Akhmadullina D.R., Fedotova E.Y.Ахмадуллина Д.Р., Федотова Е.Ю.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/1067

Language is one of the higher brain functions and the primary method of communication, so it plays a key role in human social functioning. Primary progressive aphasia, as a slowly progressive neurodegenerative disease with a clinical predominance of different speech and language disorders, is a promising model for a more detailed study of topographic distribution of language disorders. This review presents data on different clinical variants of primary progressive aphasia and the corresponding clinical and neuroanatomical correlates that have significantly expanded the modern understanding of the neural network language organization.

Речь является одной из высших корковых функций и представляет собой основной метод коммуникации, из-за чего сложно переоценить её значимость для полноценного функционирования человека в социуме. Первичная прогрессирующая афазия, будучи медленно развивающимся нейродегенеративным заболеванием с преобладанием в клинической картине разнообразных речевых нарушений, является перспективной моделью для более подробного исследования топографического распределения расстройств речи. В обзоре приводятся данные о различных клинических вариантах первичной прогрессирующей афазии, а также соответствующие им клинико-нейроанатомические корреляции, благодаря которым в значительной степени расширилось современное понимание нейросетевой организации речи.

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