Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector109510.17816/ACEN.1095ReviewsОбзорыReview ArticleDeep Brain Stimulation Withdrawal Syndrome, a Rare Life-Threatening Condition in Neurology and NeurosurgeryСиндром отмены нейростимуляции у пациентов с болезнью Паркинсона — редкое неотложное состояние в неврологии и нейрохирургииhttps://orcid.org/0000-0002-6524-4490BrilEkaterina V.БрильЕкатерина Витальевна
Russian Federation

Cand. Sci. (Med.), Assoc. Prof., Department of neurology with a course of reflexology and manual therapy, Russian Medical Academy of Continuing Professional Education; Head, Department of neurology with a course of neurosurgery, Medical and Biological University of Innovation and Continuing Education, Head, Federal Neurological Center for Extrapyramidal Diseases and Mental Health, State Research Center — Burnazyan Federal Medical Biophysical Center

канд. мед. наук, доцент каф. неврологии с курсом рефлексологии и мануальной терапии Российской медицинской академии непрерывного последипломного образования; зав. каф. неврологии с курсом нейрохирургии Медико-биологического университета инноваций и непрерывного образования, руководитель Федерального неврологического центра экстрапирамидных заболеваний и психического здоровья ГНЦ РФ — Федерального медицинского биофизического центра им. А.И. Бурназяна

e.brill@inbox.ruhttps://orcid.org/0000-0002-2120-0146TomskiyAlexey A.ТомскийАлексей Алексеевич
Russian Federation

Cand. Sci. (Med.), Assoc. Prof., Department of neurosurgery with courses in neuroscience, senior researcher, 6th Clinical department, neurosurgeon, Head, Functional neurosurgery group

канд. мед. наук, доцент каф. нейрохирургии с курсами нейронаук, с. н. с. 6-го клинического отделения, врач-нейрохирург, рук. группы функциональной нейрохирургии

alexey_tomskiy@mail.ruhttps://orcid.org/0000-0002-6412-8148GamaleyaAnna A.ГамалеяАнна Александровна
Russian Federation

neurologist, Scientific advisory department

врач-невролог научно-консультативного отделения

agamaleya@mail.ruhttps://orcid.org/0000-0002-5776-3442PoddubskayaAnna A.ПоддубскаяАнна Андреевна
Russian Federation

junior researcher, Psychiatric research group, neurologist, Scientific advisory department

м. н. с. группы психиатрических исследований, врач-невролог научно-консультативного отделения

anna.poddubsk@gmail.comhttps://orcid.org/0009-0007-2130-2410KesarevDmytriy G.КесаревДмитрий Григорьевич
Russian Federation

postgraduate student, Department of neurology with a course of neurosurgery, Medical and Biological University of Innovation and Continuing Education

аспирант каф. неврологии с курсом нейрохирургии Медико-биологического университета инноваций и непрерывного образования

kes.neurology@mail.ruhttps://orcid.org/0000-0003-2168-2138FedorovaNatalia V.ФедороваНаталия Владимировна
Russian Federation

D. Sci. (Med.), Professor, Department of neurology with a course of reflexology and manual therapy

д-р мед. наук, профессор каф. неврологии с курсом рефлексологии и мануальной терапии

Natalia.fedorova@list.ruRussian Medical Academy of Continuous Professional EducationРоссийская медицинская академия непрерывного последипломного образованияState Research Center — Burnazyan Federal Medical Biophysical CenterГосударственный научный центр Российской Федерации — Федеральный медицинский биофизический центр имени А.И. БурназянаN.N. Burdenko National Medical Research Center of NeurosurgeryНациональный медицинский исследовательский центр нейрохирургии имени академика Н.Н. Бурденко03102024183911022102202408042024Copyright ©; 2024, Bril E.V., Tomskiy A.A., Gamaleya A.A., Poddubskaya A.A., Kesarev D.G., Fedorova N.V.Copyright ©; 2024, Бриль Е.В., Томский А.А., Гамалея А.А., Поддубская А.А., Кесарев Д.Г., Федорова Н.В.2024Bril E.V., Tomskiy A.A., Gamaleya A.A., Poddubskaya A.A., Kesarev D.G., Fedorova N.V.Бриль Е.В., Томский А.А., Гамалея А.А., Поддубская А.А., Кесарев Д.Г., Федорова Н.В.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/1095

The article addresses an acute condition associated with an abrupt cessation of neurostimulation of deep brain structures, which is manifested by acute hypokinesia and rigidity with further development of akinesia, anarthria and dysphagia. This may result in the need for emergency hospitalization and admission to an intensive care unit. The article presents literature review and clinical case reports. We discuss causes and approaches to the prevention and management of acute decompensation in patients with Parkinson's disease associated with abrupt deep brain stimulation cessation.

Статья посвящена острому состоянию, связанному с внезапным прекращением стимуляции глубоких структур головного мозга, которое проявляется резким нарастанием гипокинезии и ригидности с развитием обездвиженности, анартрии и нарушений глотания, в результате чего пациенты могут быть экстренно госпитализированы, в том числе в отделение реанимации. Представлены обзор литературы и клинические наблюдения. Обсуждаются причины, пути профилактики и способы коррекции острой декомпенсации состояния у пациентов с болезнью Паркинсона, связанной с внезапным прекращением глубокой стимуляции мозга.

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