<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1234</article-id><article-id pub-id-type="doi">10.17816/ACEN.1234</article-id><article-id pub-id-type="edn">YKGNAQ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Incidence of facial palsy following microsurgical removal of vestibular schwannoma using direct electrical stimulation: a meta-analysis</article-title><trans-title-group xml:lang="ru"><trans-title>Оценка частоты развития нейропатии лицевого нерва после микрохирургического удаления вестибулярной шванномы с использованием метода прямой электрической стимуляции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9652-1457</contrib-id><contrib-id contrib-id-type="spin">2305-7580</contrib-id><name-alternatives><name xml:lang="en"><surname>Seliverstova</surname><given-names>Ekaterina G.</given-names></name><name xml:lang="ru"><surname>Селиверстова</surname><given-names>Екатерина Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), senior researcher, Emergency neurosurgery department</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, старший научный сотрудник отд. неотложной нейрохирургии, врач функциональной диагностики</p></bio><email>e.seliverstova.md@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5026-0060</contrib-id><name-alternatives><name xml:lang="en"><surname>Sinkin</surname><given-names>Mikhail V.</given-names></name><name xml:lang="ru"><surname>Синкин</surname><given-names>Михаил Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Head, Clinical neurophysiology laboratory, Emergency neurosurgery department, Acting Head, Medical neurotechnology department, Institute of Neuroscience and Neurotechnologies</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, ведущий научный сотрудник отд. неотложной нейрохирургии, руководитель группы клинической нейрофизиологии, и. о. зав. каф. медицинских нейротехнологий Института нейронаук и нейротехнологий</p></bio><email>e.seliverstova.md@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3515-8329</contrib-id><name-alternatives><name xml:lang="en"><surname>Grin</surname><given-names>Andrey A.</given-names></name><name xml:lang="ru"><surname>Гринь</surname><given-names>Андрей Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Corr. Member of the Russian Academy of Sciences, Head, Emergency neurosurgery department, Professor, Fundamental neurosurgery department</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, член-корр. РАН, зав. научным отд. неотложной нейрохирургии, профессор каф. фундаментальной нейрохирургии факультета дополнительной профессиональной подготовки</p></bio><email>e.seliverstova.md@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sklifosovsky Research Institute of Emergency Medicine</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-06-26" publication-format="electronic"><day>26</day><month>06</month><year>2025</year></pub-date><volume>19</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>52</fpage><lpage>61</lpage><history><date date-type="received" iso-8601-date="2024-11-13"><day>13</day><month>11</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2025-03-12"><day>12</day><month>03</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Seliverstova E.G., Sinkin M.V., Grin A.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Селиверстова Е.Г., Синкин М.В., Гринь А.А.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Seliverstova E.G., Sinkin M.V., Grin A.A.</copyright-holder><copyright-holder xml:lang="ru">Селиверстова Е.Г., Синкин М.В., Гринь А.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/1234">https://annaly-nevrologii.com/pathID/article/view/1234</self-uri><abstract xml:lang="en"><p><bold>Aim</bold><bold>.</bold> To determine the incidence of facial palsy (FP) following microsurgical removal of vestibular schwannoma using direct electrical stimulation.</p> <p><bold>Materials</bold><bold> </bold><bold>and</bold><bold> </bold><bold>methods</bold><bold>. </bold>The meta-analysis included 946 publications from PubMed, Google Scholar, Web of Science, and eLIBRARY.RU, of which 9 studies meeting the inclusion and exclusion criteria were selected. The total number of patients was 1875, with 278 having FP after microsurgical removal of vestibular schwannoma. The pooled mean age of patients was 46.9 [44.5; 49.4] years, with a male-to-female ratio of 1 : 1.</p> <p><bold>Results</bold><bold>. </bold>The pooled incidence rate of early postoperative FP was 16.1% (6.8–25.3%), and delayed FP was 8.7% (0.5–12.4%). At 12 months postoperatively, patients with delayed FP demonstrated better recovery outcomes of facial muscle function.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель исследования — </bold>определение частоты возникновения нейропатии лицевого нерва (НЛН) после микрохирургического удаления вестибулярной шванномы с использованием метода прямой электрической стимуляции.</p> <p><bold>Материалы и методы. </bold>В метаанализ включены 946 публикаций из баз данных PubMed, Google Scholar, Web of Science и eLIBRARY.RU, из которых отобраны 9 исследований, удовлетворяющих критериям включения и исключения. Общее число пациентов составило 1875 человек, у 278 из них после микрохирургического удаления вестибулярной шванномы развилась НЛН. Обобщённый средний возраст пациентов составил 46,9 [44,5; 49,4] года, соотношение мужчин и женщин 1 : 1.</p> <p><bold>Результаты. </bold>Обобщённый показатель частоты развития ранней послеоперационной НЛН составил 16,1% (6,8–25,3%), отсроченной — 8,7% (0,5–12,4%). Через 12 мес. после операции у пациентов с отсроченной НЛН наблюдали лучшие результаты восстановления функции мимической мускулатуры.</p></trans-abstract><kwd-group xml:lang="en"><kwd>vestibular schwannoma</kwd><kwd>facial palsy</kwd><kwd>intraoperative neurophysiological monitoring</kwd><kwd>cerebellopontine angle tumor</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вестибулярная шваннома</kwd><kwd>нейропатия лицевого нерва</kwd><kwd>интраоперационный нейрофизиологический мониторинг</kwd><kwd>опухоль мостомозжечкового угла</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Propp JM, McCarthy BJ, Davis FG, Preston-Martin S. Descriptive epidemiology of vestibular schwannomas. Neuro Oncol. 2006;8(1):1–11. doi: 10.1215/S1522851704001097</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ahn MS, Jackler RK, Lustig LR. The early history of the neurofibromatoses. Evolution of the concept of neurofibromatosis type 2. Arch Otolaryngol Head Neck Surg. 1996; 122(11):1240–1249. doi: 10.1001/archotol.1996.01890230086016</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Ballance CA. Some points in the surgery of the brain and its membranes. 2nd ed. London; 1907.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Koerbel A, Gharabaghi A, Safavi-Abbasi S, et al. Evolution of vestibular schwannoma surgery: the long journey to current success. Neurosurg Focus. 2005;18(4):e10. doi: 10.3171/foc.2005.18.4.11</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Krause F, Haubold A, Thorek M. Surgery of the brain and spinal cord, based on personal experiences. New York; 1912.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Delgado TE, Buchheit WA, Rosenholtz HR, Chrissian S. Intraoperative monitoring of facial muscle evoked responses obtained by intracranial stimulation of the facial nerve: a more accurate technique for facial nerve dissection. Neurosurgery. 1979;4(5):418–421. doi: 10.1227/00006123-197905000-00007</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Machetanz K, Roegele M, Liebsch M, et al. Predictive value of facial motor-evoked potential and electromyography for facial motor function in vestibular schwannoma surgery. Acta Neurochir (Wien). 2024;166(1):23. doi: 10.1007/s00701-024-05927-0</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Arnoldner C, Mick P, Pirouzmand F, et al. Facial nerve prognostication in vestibular schwannoma surgery: the concept of percent maximum and its predictability. Laryngoscope. 2013;123(10):2533–2538. doi: 10.1002/lary.24083</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Morton RP, Ackerman PD, Pisansky MT, et al. Prognostic factors for the incidence and recovery of delayed facial nerve palsy after vestibular schwannoma resection. J Neurosurg. 2011;114(2):375–380. doi: 10.3171/2010.5.JNS091854</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Carlstrom LP, Copeland WR 3rd, Neff BA, et al. Incidence and risk factors of delayed facial palsy after vestibular schwannoma resection. Neurosurgery. 2016;78(2):251–255. doi: 10.1227/NEU.0000000000001015</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Chang S, Makarenko S, Despot I, et al. Differential recovery in early- and late-onset delayed facial palsy following vestibular schwannoma resection. Oper Neurosurg (Hagerstown). 2020;18(1):34–40. doi: 10.1093/ons/opz083</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Jia XH, Gao Z, Lin NE, et al. Delayed facial nerve paralysis after vestibular schwannoma resection. World Neurosurg. 2023;170:e431–e435. doi: 10.1016/j.wneu.2022.11.036</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kheirkhah M, Brodoehl S, Leistritz L, et al. Abnormal emotional processing and emotional experience in patients with peripheral facial nerve paralysis: an MEG study. Brain Sci. 2020;10(3):147. doi: 10.3390/brainsci10030147</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Coulson SE, O’dwyer NJ, Adams RD, Croxson GR. Expression of emotion and quality of life after facial nerve paralysis. Otol Neurotol. 2004;25(6):1014–1019. doi: 10.1097/00129492-200411000-00026</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Nabhan A, Ahlhelm F, Reith W, et al. Function of the facial nerve after operative treatment of acoustic neurinomas. Influence of intraoperative monitoring. Nervenarzt. 2005;76(2):170–174. doi: 10.1007/s00115-004-1778-4</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. doi: 10.1371/journal.pmed.1000097</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Реброва О.Ю., Федяева В.К. Вопросник для оценки риска систематических ошибок в нерандомизированных сравнительных исследованиях: русскоязычная версия шкалы Ньюкасл–Оттава. Медицинские технологии. Оценка и выбор. 2016;3(25):14–19.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Rebrova OYu, Fediaeva VK. The Questionnaire to assess the risk of systematic bias in non-randomized comparative studies: the Russian-language version of the Newcastle–Ottawa scale. Medical technologies. Evaluation and selection. 2016;3(25):14–19.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Arlt F, Kasper J, Winkler D, et al. Facial nerve function after microsurgical resection in vestibular schwannoma under neurophysiological monitoring. Front. Neurol. 2022; 13:850326. doi: 10.3389/fneur.2022.850326</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Gazia F, Callejo À, Pérez-Grau M, et al. Pre- and intra-operative prognostic factors of facial nerve function in cerebellopontine angle surgery. Eur Arch Otorhinolaryngol. 2023;280(3):1055–1062. doi: 10.1007/s00405-022-07556-8</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Grant GA, Rostomily RR, Kim DK, et al. Delayed facial palsy after resection of vestibular schwannoma. J Neurosurg. 2002;97(1):93–96. doi: 10.3171/jns.2002.97.1.0093</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Karanth VKKS, Yerragunta T, Sampath N, et al. Multimodal intraoperative neurophysiological monitoring with special emphasis on facial MEPs for facial nerve preservation in vestibular schwannoma surgeries: Surgical nuances and outcome predictability. Indian J Physiol Pharmacol. 2024;68(2):118–125. doi: 10.25259/ijpp_77_2024</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Ren Y, MacDonald BV, Tawfik KO, et al. Clinical predictors of facial nerve outcomes after surgical resection of vestibular schwannoma. Otolaryngol Head Neck Surg. 2021;164(5):1085–1093. doi: 10.1177/0194599820961389</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Yawn RJ, Dedmon MM, Xie D, et al. Delayed facial nerve paralysis after vestibular schwannoma resection. J Neurol Surg B Skull Base. 2018;80(3):283–286. doi: 10.1055/s-0038-1669941</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Starnoni D, Giammattei L, Cossu G, et al. Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section. Acta Neurochir (Wien). 2020;162(11):2595–2617. doi: 10.1007/s00701-020-04491-7</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Prasad SC, Patnaik U, Grinblat G, et al. Decision making in the wait-and-scan approach for vestibular schwannomas: is there a price to pay in terms of hearing, facial nerve, and overall оutcomes? Neurosurgery. 2018;83(5):858–870. doi: 10.1093/neuros/nyx568</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Palavani LB, Batista S, Andreão FF, et al. Retrosigmoid versus middle fossa approach for hearing and facial nerve preservation in vestibular schwannoma surgery: a systematic review and comparative meta-analysis. J Clin Neurosci. 2024;124:1–14. doi: 10.1016/j.jocn.2024.04.007</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Акулов М.А., Таняшин С.В., Шиманский В.Н. и др. Эффективность ботулинотерапии в лечении отсроченной нейропатии лицевого нерва после удаления невриномы слухового нерва. Журнал «Вопросы нейрохирургии» им. Н.Н. Бурденко. 2018;82(5):81–87. Akulov MA, Taniashin SV, Shimanskii VN, et al. The efficacy of botulinum therapy in treatment of delayed facial palsy after resection of vestibular schwannoma. Burdenko’s Journal of Neurosurgery. 2018;82(5):81–87. doi: 10.17116/neiro20188205181</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Tos M, Youssef M, Thomsen J, Turgut S. Causes of facial nerve paresis after translabyrinthine surgery for acoustic neuroma. Ann Otol Rhinol Laryngol. 1992;101(10):821–826. doi: 10.1177/000348949210101004</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Henz GD, Gonçalves RF, Nogueira GN, Isolan GR. Latest advances in facial nerve intraoperative monitoring for vestibular schwannoma — up to date 2024. Contemporary J. 2024;4(8):1–19. doi: 10.56083/RCV4N8-126</mixed-citation></ref></ref-list></back></article>
