<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1294</article-id><article-id pub-id-type="doi">10.17816/ACEN.1294</article-id><article-id pub-id-type="edn">ZEXYSS</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Quantitative approach in assessing standard brachial plexus MRI for the diagnosis of multifocal motor neuropathy and Lewis–Sumner syndrome</article-title><trans-title-group xml:lang="ru"><trans-title>Роль количественного подхода в оценке стандартной МРТ плечевых сплетений в диагностике мультифокальной моторной нейропатии и синдрома Льюиса–Самнера</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2285-2725</contrib-id><name-alternatives><name xml:lang="en"><surname>Sinkova</surname><given-names>Viktoriya V.</given-names></name><name xml:lang="ru"><surname>Синькова</surname><given-names>Виктория Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student, Radiology department</p></bio><bio xml:lang="ru"><p>аспирант отдела лучевой диагностики</p></bio><email>000564321@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9093-344X</contrib-id><name-alternatives><name xml:lang="en"><surname>Morozova</surname><given-names>Sofya N.</given-names></name><name xml:lang="ru"><surname>Морозова</surname><given-names>Софья Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), researcher, Radiology department</p></bio><bio xml:lang="ru"><p>канд. мед. наук, н. с., врач-рентгенолог отдела лучевой диагностики</p></bio><email>morozova@neurology.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7924-3405</contrib-id><name-alternatives><name xml:lang="en"><surname>Grishina</surname><given-names>Daria A.</given-names></name><name xml:lang="ru"><surname>Гришина</surname><given-names>Дарья Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Head, Center for peripheral nervous system diseases</p></bio><bio xml:lang="ru"><p>канд. мед. наук, руководитель Центра заболеваний периферической нервной системы</p></bio><email>000564321@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9538-9690</contrib-id><name-alternatives><name xml:lang="en"><surname>Tumilovich</surname><given-names>Taisiya A.</given-names></name><name xml:lang="ru"><surname>Тумилович</surname><given-names>Таисия Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>neurologist, Center for peripheral nervous system diseases</p></bio><bio xml:lang="ru"><p>врач-невролог Центра заболеваний периферической нервной системы</p></bio><email>tumilovich.taisiya@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3956-6362</contrib-id><name-alternatives><name xml:lang="en"><surname>Suponeva</surname><given-names>Natalia A.</given-names></name><name xml:lang="ru"><surname>Супонева</surname><given-names>Наталья Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Corr. Member of RAS, Director, Institute of Neurorehabilitation and Rehabilitation Medicine</p></bio><bio xml:lang="ru"><p>д-р мед. наук, член-корреспондент РАН, профессор, директор Института нейрореабилитации и восстановительной медицины</p></bio><email>suponeva@neurology.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3820-4554</contrib-id><name-alternatives><name xml:lang="en"><surname>Krotenkova</surname><given-names>Marina V.</given-names></name><name xml:lang="ru"><surname>Кротенкова</surname><given-names>Марина Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Head, Radiology department</p></bio><bio xml:lang="ru"><p>д-р мед. наук, руководитель Отдела лучевой диагностики</p></bio><email>krotenkova_mrt@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Center of Neurology and Neurosciences</institution></aff><aff><institution xml:lang="ru">Российский центр неврологии и нейронаук</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-12-25" publication-format="electronic"><day>25</day><month>12</month><year>2025</year></pub-date><volume>19</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>5</fpage><lpage>13</lpage><history><date date-type="received" iso-8601-date="2025-02-19"><day>19</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-04-01"><day>01</day><month>04</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Sinkova V.V., Morozova S.N., Tumilovich T.A., Suponeva N.A., Krotenkova M.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Синькова В.В., Морозова С.Н., Тумилович Т.А., Супонева Н.А., Кротенкова М.В.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Sinkova V.V., Morozova S.N., Tumilovich T.A., Suponeva N.A., Krotenkova M.V.</copyright-holder><copyright-holder xml:lang="ru">Синькова В.В., Морозова С.Н., Тумилович Т.А., Супонева Н.А., Кротенкова М.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/1294">https://annaly-nevrologii.com/pathID/article/view/1294</self-uri><abstract xml:lang="en"><p><bold>Introduction</bold><bold>.</bold> Among various chronic polyneuropathies, there are conditions that pose challenges for differential diagnosis: multifocal motor neuropathy (MMN) and Lewis–Sumner syndrome (LSS). The potential of magnetic resonance imaging (MRI) to objectively assess pathological changes in the nerve structures of brachial plexuses remains highly relevant for the diagnosis and differential diagnosis of MMN and LSS.</p> <p><bold>The</bold><bold> </bold><bold>aim</bold> of this study is to determine the diagnostic value of quantitative methods for assessing MRI signal intensity and thickness measurements of brachial plexus neural elements in differentiating LSS and MMN.</p> <p><bold>Materials</bold><bold> </bold><bold>and</bold><bold> </bold><bold>methods</bold><bold>.</bold> The study included 59 patients: 26 diagnosed with MMN, 33 with LSS, along with 15 healthy volunteers.</p> <p><bold>Results</bold><bold>.</bold> When comparing the combined patient group (regardless of diagnosis) with healthy controls, both nerve thickness and signal intensity coefficient were significantly higher in patients. Additionally, disease-specific threshold values for signal intensity coefficient were established for each condition.</p> <p><bold>Conclusion</bold><bold>.</bold> The analysis of signal intensity coefficients LSS and MMN demonstrates that quantitative assessment of MRI signal intensity from the anterior rami of spinal nerves forming brachial plexuses provides additional diagnostic information about pathological changes and facilitates accurate diagnosis. This approach enables earlier initiation of pathogenetic therapy, reduces disability rates, and shortens the duration of patient incapacitation.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение.</bold> Среди множества хронических полинейропатий выделяют нозологические формы, трудно поддающиеся дифференциальной диагностике: мультифокальную моторную нейропатию (ММН) и синдром Льюиса–Самнера (СЛС). Актуальным для диагностики и дифференциальной диагностики ММН и СЛС является вопрос о возможности объективизации при магнитно-резонансной томографии (МРТ) изменений нервных структур плечевых сплетений.</p> <p><bold>Цель </bold>исследования — определение роли количественных методов оценки интенсивности МР-сигнала и толщины нервных элементов плечевых сплетений для диагностики и дифференциальной диагностики СЛС и ММН.</p> <p><bold>Материалы и методы.</bold> В исследование были включены 59 пациентов: 26 — с диагнозом ММН, 33 — с диагнозом СЛС, а также 15 здоровых добровольцев.</p> <p><bold>Результаты.</bold> При сравнении группы пациентов (без деления по нозологиям) с группой здоровых испытуемых толщина и коэффициент интенсивности были значимо больше у пациентов по сравнению с контрольной группой. Кроме того, были определены пороговые показатели коэффициента интенсивности для каждой нозологии.</p> <p><bold>Заключение.</bold> Полученные результаты анализа коэффициента интенсивности при СЛС и ММН позволяют сделать вывод о том, что использование предлагаемого количественного способа оценки интенсивности МР-сигнала от передних ветвей спинно-мозговых нервов, формирующих плечевые сплетения, может позволить получить дополнительную информацию о наличии патологических изменений и ускорить постановку верного диагноза. Это будет способствовать более раннему назначению патогенетической терапии, снижению уровня инвалидизации и сокращению срока нетрудоспособности пациентов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>dysimmune neuropathies</kwd><kwd>Lewis–Sumner syndrome</kwd><kwd>multifocal motor neuropathy</kwd><kwd>brachial plexus magnetic resonance imaging</kwd><kwd>signal intensity coefficient</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дизиммунные нейропатии</kwd><kwd>синдром Льюиса–Самнера</kwd><kwd>мультифокальная моторная нейропатия</kwd><kwd>магнитно-резонансная томография плечевых сплетений</kwd><kwd>коэффициент интенсивности</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Van den Bergh P, van Doorn P, Hadden R, et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint Task Force-Second revision. Eur J Neurol. 2021;28(11):3556–3583. doi: 10.1111/ene.14959</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society — first revision. J Peripher Nerv Syst. 2010;15(4):295–301. doi: 10.1111/j.1529-8027.2010.00290.x</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Parry GJ, Sumner AJ. Multifocal motor neuropathy. Neurol Clin. 1992;10(3):671–684.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Van den Bergh PYK, van Doorn PA, Hadden RDM, et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint Task Force—Second revision. J Peripher Nerv Syst. 2021;26(3):242–268. doi: 10.1111/jns.12455</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Kaji R, Kimura J. Facts and fallacies on anti-GM1 antibodies: physiology of motor neuropathies. Brain. 1999;122(Pt 5):797–798. doi: 10.1093/brain/122.5.797</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Pahud de Mortanges A, Sinaci E, Salvador D, et al. GLP-1 Receptor agonists and coronary arteries: from mechanisms to events. Front Pharmacol. 2022;13:856111. doi: 10.3389/fphar.2022.856111</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Гапешин Р.А., Баранцевич Е.Р., Яковлев А.А. Патогенез, особенности клинической картины и лабораторной диагностики хронической воспалительной демиелинизирующей полинейропатии. Учёные записки СПбГМУ им. акад. И. П. Павлова. 2018;25(3):14–24. Gapeshin RA, Barantsevich ER, Yakovlev AA. Pathogenesis, clinical and laboratory features of chronic inflammatory demyelinating polyneuropathy. The Scientific Notes of the Pavlov University. 2018;25(3):14–24. doi: 10.24884/1607-4181-2018-25-3-14-24</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Супонева Н.А., Наумова Е.С., Гнедовская Е.В. Хроническая воспалительная демиелинизирующая полинейропатия у взрослых: принципы диагностики и терапия первой линии. Нервно-мышечные болезни. 2016;6(1):44–53. Suponeva NА, Naumovа ES, Gnedovskaya EV. Chronic inflammatory demyelinating polyneuropathy in adults: diagnostic approaches and first line therapy. Neuromuscular Diseases. 2016;6(1):44–53. doi: 10.17650/2222-8721-2016-6-1-44-53</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Ризванова А.С., Гришина Д.А., Супонева Н.А. Клиническая гетерогенность хронической воспалительной демиелинизирующей полинейропатии: трудности диагностики. Альманах клинической медицины. 2020;48(1):56–64. Rizvanova AS, Grishina DA, Suponeva NA. Clinical heterogeneity of chronic inflammatory demyelinating polyneuropathy: diagnostic challenges. Almanac of Clinical Medicine. 2020;48(1):56–64. doi: 10.18786/2072-0505-2020-48-007</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Tanaka K, Mori N, Yokota Y, Suenaga T. MRI of the cervical nerve roots in the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy: a single — institution, retrospective case-control study. BMJ Open. 2013;3(8):e003443. doi: 10.1136/bmjopen-2013-003443</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Tazawa K, Matsuda M, Yoshida T, et al. Spinal nerve root hypertrophy on MRI: clinical significance in the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy. Intern Med. 2008;47(23):2019–2024. doi: 10.2169/internalmedicine.47.1272</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Lozeron P, Lacour MC, Vandendries C, et al. Contribution of plexus MRI in the diagnosis of atypical chronic inflammatory demyelinating polyneuropathies. J Neurol Sci. 2016; 360:170–175. doi: 10.1016/j.jns.2015.11.048</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kronlage M, Bäumer P, Pitarokoili K, et al. Large coverage MR neurography in CIDP: diagnostic accuracy and electrophysiological correlation. J Neurol. 2017;264(7):1434–1443. doi: 10.1007/s00415-017-8543-7</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Simmons A, Tofts PS, Barker GJ, Arridge SR. Sources of intensity nonuniformity in spin echo images at 1.5 T. Magn Reson Med. 1994;32(1):121–128. doi: 10.1002/mrm.1910320117</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Chen Y, Haacke EM, Li J. Peripheral nerve magnetic resonance imaging. F1000Res. 2019;8:F1000 Faculty Rev-1803. doi: 10.12688/f1000research.19695.1</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Basser PJ, Pierpaoli C. Microstructural features measured using diffusion tensor imaging. J Magn Reson B. 1996;111(3):209–219. doi: 10.1006/jmrb.1996.0086</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Carré A, Klausner G, Edjlali M, et al. Standardization of brain MR images across machines and protocols: bridging the gap for MRI-based radiomics. Sci Rep. 2020;10(1):12340. doi: 10.1038/s41598-020-69298-z</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Kollmer J., Bendszus M. Magnetic resonance neurography: improved diagnosis of peripheral neuropathies. Neurotherapeutics. 2021;18(4):2368–2383. doi: 10.1007/s13311-021-01166-8</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Chhabra A, Andreisek G, Soldatos T, et al. MR neurography: past, present, and future. AJR Am J Roentgenol. 2011;197(3):583–591. doi: 10.2214/AJR.10.6012</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Andreisek G, Burg D, Studer A, Weishaupt D. Upper extremity peripheral neuropathies: role and impact of MR imaging on patient management. Eur Radiol. 2008;18(9):1953–1961. doi: 10.1007/s00330-008-0940-y</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>van Rosmalen MHJ, Goedee HS, van der Gijp A, et al. Low interrater reliability of brachial plexus MRI in chronic inflammatory neuropathies. Muscle Nerve. 2020;61(6):779–783. doi: 10.1002/mus.26821</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Bischoff C, Kollmer J, Schulte-Mattler W. State-of-the-art diagnosis of peripheral nerve trauma: clinical examination, electrodiagnostic, and imaging. In: Modern concepts of peripheral nerve repair. Haastert-Talini K, Assmus H, Antoniadis G (eds.). Cham; 2017. doi: 10.1007/978-3-319-52319-4_2</mixed-citation></ref></ref-list></back></article>
