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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1390</article-id><article-id pub-id-type="doi">10.17816/ACEN.1390</article-id><article-id pub-id-type="edn">ZGYMQS</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical analysis</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинический разбор</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Intraoperative neurophysiological monitoring of trigeminal nerve function during giant vestibular schwannoma resection: blink reflex monitoring</article-title><trans-title-group xml:lang="ru"><trans-title>Интраоперационный нейрофизиологический мониторинг функции тройничного нерва при резекции гигантских вестибулярных шванном: мониторинг мигательного рефлекса</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8748-7138</contrib-id><name-alternatives><name xml:lang="en"><surname>Miftakhova</surname><given-names>Diliara Z.</given-names></name><name xml:lang="ru"><surname>Мифтахова</surname><given-names>Диляра Зуфаровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>assistant professor, Functional diagnostics department; physician, Functional diagnostics department No. 2</p></bio><bio xml:lang="ru"><p>ассистент каф. функциональной диагностики; врач отделения функциональной диагностики № 2</p></bio><email>dmiftakhova@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0134-1005</contrib-id><name-alternatives><name xml:lang="en"><surname>Pichugin</surname><given-names>Arseniy A.</given-names></name><name xml:lang="ru"><surname>Пичугин</surname><given-names>Арсений Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Head, Neurosurgery department; physician, Neurosurgery department</p></bio><bio xml:lang="ru"><p>канд. мед. наук, зав. каф. нейрохирургии; врач отделения нейрохирургии</p></bio><email>arsenicus@yandex.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5311-2577</contrib-id><name-alternatives><name xml:lang="en"><surname>Ivanov</surname><given-names>Roman V.</given-names></name><name xml:lang="ru"><surname>Иванов</surname><given-names>Роман Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>resident in neurology, Neurosurgery department</p></bio><bio xml:lang="ru"><p>ординатор каф. нейрохирургии</p></bio><email>ivanovrv@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-7435-5463</contrib-id><name-alternatives><name xml:lang="en"><surname>Mukhamadieva</surname><given-names>Daniia K.</given-names></name><name xml:lang="ru"><surname>Мухамадиева</surname><given-names>Дания Камилевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head, Functional diagnostics department No. 2</p></bio><bio xml:lang="ru"><p>зав. отд. функциональной диагностики</p></bio><email>daniakamil@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Казанская государственная медицинская академия — филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Interregional Clinical Diagnostic Center</institution></aff><aff><institution xml:lang="ru">Межрегиональный клинико-диагностический центр</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Kazan State Medical University</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2026</year></pub-date><volume>20</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>100</fpage><lpage>108</lpage><history><date date-type="received" iso-8601-date="2025-06-14"><day>14</day><month>06</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-09-05"><day>05</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Miftakhova D.Z., Pichugin A.A., Ivanov R.V., Mukhamadieva D.K.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Мифтахова Д.З., Пичугин А.А., Иванов Р.В., Мухамадиева Д.К.</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Miftakhova D.Z., Pichugin A.A., Ivanov R.V., Mukhamadieva D.K.</copyright-holder><copyright-holder xml:lang="ru">Мифтахова Д.З., Пичугин А.А., Иванов Р.В., Мухамадиева Д.К.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/1390">https://annaly-nevrologii.com/pathID/article/view/1390</self-uri><abstract xml:lang="en"><p><bold>Introduction. </bold>Intraoperative neurophysiological monitoring is as crucial for preserving trigeminal nerve function during vestibular schwannoma (VS) resections as it is for monitoring facial nerve function.</p> <p><bold>Study aim:</bold> To analyze the intraoperative reproducibility of the blink reflex (BR), assess its relationship with transcranial corticobulbar motor evoked potentials (CoMEP) and electromyographic monitoring data during VS removal, and determine its association with postoperative trigeminal nerve function.</p> <p><bold>Materials and methods.</bold> The results of surgical treatment in the neurosurgery department of the Interregional Clinical Diagnostic Center in 2024–2025 were retrospectively analyzed for 17 patients with VS in whom BR was recorded intraoperatively. Standard modalities of intraoperative monitoring were studied: spontaneous and triggered electromyography, CoMEPs, somatosensory evoked potentials from the median nerve bilaterally, and electromyography of the masseter and temporalis muscles.</p> <p><bold>Results.</bold> Intraoperatively, BR was reliably recorded in 82% of patients prior to VS removal. In patients with severe preoperative impairment of the trigeminal and facial nerves, BR was not detected intraoperatively. However, in 1 patient with significant deficits of the V and VII cranial nerves, BR was identified intraoperatively. In 3 (8%) patients, an abrupt loss of BR was recorded during monitoring. In 2 of these patients, the amplitude of CoMEPs decreased simultaneously; in 1 patient the decrease was critical, in another by 40%, and in 1 patient the CoMEPs remained stable. In cases of an acute loss of BR, patients developed sensory changes in the ipsilateral half of the face in the postoperative period.</p> <p><bold>Conclusion.</bold> The method of BR recording during VS resection may become a valuable addition to intraoperative monitoring of CoMEPs and electromyography.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение. </bold>При резекциях вестибулярных шванном (ВШ) интраоперационный нейрофизиологический мониторинг имеет не меньшее значение в сохранении функции тройничного нерва, чем мониторинг функции лицевого нерва.</p> <p><bold>Цель </bold>исследования: проанализировать воспроизводимость мигательного рефлекса интраоперационно, оценить взаимосвязь с транскраниальными кортиконуклеарными вызванными потенциалами (ВП) и данными электромиографического мониторинга во время операций удаления ВШ и определить корреляцию с послеоперационной функцией тройничного нерва.</p> <p><bold>Материалы и методы.</bold> Ретроспективно проанализированы результаты хирургического лечения в нейрохирургическом отделении Межрегионального клинико-диагностического центра в 2024–2025 гг. 17 пациентов с ВШ, у которых интраоперационно регистрировался мигательный рефлекс. Изучали стандартные модальности интраоперационного мониторинга: спонтанную и триггерную электромиографию, кортиконуклеарные моторные ВП, соматосенсорные ВП с nervus medianus с двух сторон и электромиографию с жевательной и височной мышц.</p> <p><bold>Результаты.</bold> Интраоперационно у 82% пациентов до удаления ВШ достоверно регистрировался мигательный рефлекс. У пациентов с грубым дооперационным поражением тройничного и лицевого нервов интраоперационно мигательный рефлекс не определялся. Однако у 1 пациента с выраженным дефицитом V и VII нервов интраоперационно мигательный рефлекс идентифицировался. У 3 (8%) пациентов в течение мониторинга было зафиксировано резкое исчезновение мигательного рефлекса. При этом у 2 пациентов одновременно снизилась амплитуда кортиконуклеарных ВП, у 1 пациента — критично, у 1 — на 40%, у 1 — кортиконуклеарные ВП оставались стабильными. При резком исчезновении мигательного рефлекса у пациентов в послеоперационном периоде возникали чувствительные изменения в ипсилатеральной половине лица.</p> <p><bold>Заключение.</bold> Метод регистрации мигательного рефлекса во время резекции ВШ может стать ценным дополнением к интраоперационному мониторингу кортиконуклеарных ВП и электромиографии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acoustic neuromas</kwd><kwd>cranial nerve schwannomas</kwd><kwd>intraoperative neurophysiological monitoring</kwd><kwd>blink reflex</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>невриномы слухового нерва</kwd><kwd>шванномы черепных нервов</kwd><kwd>интраоперационный нейрофизиологический мониторинг</kwd><kwd>мигательный рефлекс</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Acioly MA, Liebsch M, de Aguiar PH, Tatagiba M. 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