Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector142410.17816/ACEN.1424VISMZTClinical analysisКлинический разборResearch ArticleLumbosacral plexopathy associated with monoclonal gammopathy of clinical (neurological) significanceПояснично-крестцовая плексопатия, ассоциированная с моноклональной гаммапатией клинического (неврологического) значенияhttps://orcid.org/0000-0003-2026-5199NarbutAnna M.НарбутАнна Михайловна
Russian Federation

neurologist, functional diagnostics physician, Center for peripheral nervous system diseases, Institute of Clinical and Preventive Neurology

врач-невролог, врач функциональной диагностики Центра заболеваний периферической нервной системы Института клинической и профилактической неврологии

narbut.anna.m@gmail.comhttps://orcid.org/0000-0002-7924-3405GrishinаDaria A.ГришинаДарья Александровна
Russian Federation

D. Sci. (Med.), Head, Center for peripheral nervous system diseases, Institute of Clinical and Preventive Neurology

д-р мед. наук, рук. Центра заболеваний периферической нервной системы Института клинической и профилактической неврологии

shevchuk.d.v@neurology.ruhttps://orcid.org/0000-0003-3956-6362SuponevaNatalia A.СупоневаНаталья Александровна
Russian Federation

Dr. Sci. (Med.), Corr. Member of RAS, Director, Institute of Neurorehabilitation

д-р мед. наук, профессор, член-корреспондент РАН, директор Института нейрореабилитации и восстановительной медицины

slotina@neurology.ruhttps://orcid.org/0000-0003-4950-523XGrachevAlexander E.ГрачёвАлександр Евгеньевич
Russian Federation

Cand. Sci. (Med.), hematologist, Department of chemotherapy of hematological diseases

канд. мед. наук, врач-гематолог отд. химиотерапии гематологических заболеваний

gra4al@yandex.ruRussian Center of Neurology and NeurosciencesРоссийский центр неврологии и нейронаукNational Medical Research Center for HematologyНациональный медицинский исследовательский центр гематологии300620262021091161509202504022026Copyright ©; 2026, Narbut A.M., Grishinа D.A., Suponeva N.A., Grachev A.E.Copyright ©; 2026, Нарбут А.М., Гришина Д.А., Супонева Н.А., Грачёв А.Е.2026Narbut A.M., Grishinа D.A., Suponeva N.A., Grachev A.E.Нарбут А.М., Гришина Д.А., Супонева Н.А., Грачёв А.Е.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/1424

We present a case series of lumbosacral plexopathy associated with clinically (neruologically) signficant monoclonal gammopathy. The aim of this publication is to demonstrate an atypical (non-polyneuritic) pattern of peripheral nervous system involvement in patients with monoclonal gammopathy. Possible therapeutic strategies for this patient population and their potential efficacy are discussed. In patients with progressive unilateral or bilateral lumbosacral plexopathy common causes should be excluded and serum protein electrophoresis with immunofixation should be performed; if positive, the patient should be referred to an hematologic oncologist to rule out the onset of a lymphoproliferative disease.

Представлена серия клинических случаев пояснично-крестцовой плексопатии, ассоциированной с моноклональной гаммапатией клинического (неврологического) значения. Целью публикации является демонстрация атипичного (не полиневритического) паттерна поражения периферической нервной системы у пациентов с моноклональной гаммапатией. Обсуждены возможные варианты терапевтической тактики данной категории пациентов и её потенциальная эффективность. Показано, что при наличии клинической картины прогрессирующей односторонней или двусторонней пояснично-крестцовой плексопатии, помимо исключения частых причин её развития, следует направлять пациентов на электрофорез белков сыворотки с иммунофиксацией, а при положительном результате — к онкогематологу с целью исключения дебюта лимфопролиферативного заболевания.

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