Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector18110.17816/psaic181ReviewsОбзорыUnknownMyeloproliferative diseases and ischemic strokeМиелопролиферативные заболевания и ишемический инсультhttps://orcid.org/0000-0002-5883-8119TanashyanMarine M.ТанашянМаринэ Мовсесовна
Russian Federation

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

д.м.н., профессор, член-корреспондент РАН, зам. директора по научной работе, рук. 1-го неврологического отделения

angionev@gmail.comhttps://orcid.org/0000-0002-4626-6520KuznetsovaPolina I.КузнецоваПолина Игоревна
Russian Federation

Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department

к.м.н., врач-невролог, н.с. 1-го неврологического отделения

angionev@gmail.comLagodaOlga V.ЛагодаОльга Викторовна
Russian Federation
angionev@gmail.comShabalinaAlla A.ШабалинаАлла Анатольевна
Russian Federation
angionev@gmail.comSubortsevaI. N.СуборцеваИ. Н.
Russian Federation
angionev@gmail.comMelikyanA. L.МеликянA. Л.
Russian Federation
angionev@gmail.comResearch Center of NeurologyФГБНУ «Научный центр неврологии»Research Center of Hematology, Ministry of HealthФГБУ Гематологический научный центр Минздрава России0906201482414501022017Copyright ©; 2014, Tanashyan M.M., Kuznetsova P.I., Lagoda O.V., Shabalina A.A., Subortseva I.N., Melikyan A.L.Copyright ©; 2014, Tanashyan M.M., Kuznetsova P.I., Lagoda O.V., Shabalina A.A., Subortseva I.N., Melikyan A.L.2014Tanashyan M.M., Kuznetsova P.I., Lagoda O.V., Shabalina A.A., Subortseva I.N., Melikyan A.L.Tanashyan M.M., Kuznetsova P.I., Lagoda O.V., Shabalina A.A., Subortseva I.N., Melikyan A.L.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/181

Myeloproliferative diseases (MPD) comprise a group of clonal pathology resulting from genetic alterations at a stem cell level. WHO (2008) divides MPD into several “classical” forms – polycythemia vera, essential thrombocytemia, and primary myelofibrosis. Haemorheologic and haemostatic disturbances have been widely accepted as a significant (in some cases – primary) cause of acute and/or chronic cerebrovascular disease. A pre-existing MPD may potentiate and accelerate the development of circulatory alterations, including those occurring in the brain tissue, leading to ischemic stroke. The present article comprises a literature review on this uncommon pathology, as well as a clinical presentation of a stroke case in a patient with underlying MPD (Vaquez’ disease).

Миелопролиферативные заболевания (МПЗ) – это клональные заболевания, возникающие в результате генетических поломок на уровне стволовой клетки. Согласно классификации ВОЗ (2008), в группу классических МПЗ: включены истинная полицитемия (ИП), эссенциальная тромбоцитемия (ЭТ), первичный миелофиброз (ПМФ). Общеизвестна значительная, а в ряде случаев – ведущая роль нарушений в системах гемореологии и гемостаза в генезе острых и хронических нарушений мозгового кровообращения (НМК). Существующее МПЗ может потенцировать и ускорить развитие микроциркуляторных расстройств, в том числе в веществе головного мозга, с реализацией НМК по типу гемореологической микроокклюзии. Представлен обзор литературы по данной малоизученной проблеме, а также клиническое описание случая развития ишемического инсульта на фоне МПЗ (болезни Вакеза).

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