Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector21810.17816/psaic218TechnologiesТехнологииUnknownResting-state fMRI: new possibilities for studying physiology and pathology of the brainФункциональная магнитно- резонансная томография покоя: новые возможности изучения физиологии и патологии мозгаSeliverstovaE. V.СеливерстоваE. В.
Russian Federation
doctor.goody@gmail.comhttps://orcid.org/0000-0002-6400-6378SeliverstovYury A.СеливёрстовЮрий Александрович
Russian Federation

Cand. Sci. (Med.), senior researcher, Scientific advisory department

к.м.н., с.н.с. Научно-консультативного отделения

doctor.goody@gmail.comhttps://orcid.org/0000-0001-5539-245XKonovalovRodion N.КоноваловРодион Николаевич
Russian Federation

Cand. Sci. (Med.), senior researcher, Neuroradiology department

к.м.н., с.н.с. отд. лучевой диагностики

doctor.goody@gmail.comhttps://orcid.org/0000-0002-2704-6282IllarioshkinSergey N.ИллариошкинСергей Николаевич
Russian Federation

D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research

д.м.н., проф., член-корр. РАН, зам. директора по научной работе, рук. отдела исследований мозга

doctor.goody@gmail.comResearch Center of NeurologyФГБНУ «Научный центр неврологии»0912201374394402022017Copyright ©; 2013, Seliverstova E.V., Seliverstov Y.A., Konovalov R.N., Illarioshkin S.N.Copyright ©; 2013, Seliverstova E.V., Seliverstov Y.A., Konovalov R.N., Illarioshkin S.N.2013Seliverstova E.V., Seliverstov Y.A., Konovalov R.N., Illarioshkin S.N.Seliverstova E.V., Seliverstov Y.A., Konovalov R.N., Illarioshkin S.N.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/218

A new method, resting-state fMRI, has been proposed recentl for studying basic sensory, emotional, and cognitive processes in healthy and neurologically affected subjects. It allows assessing spontaneous co-activation of different CNS regions in rest on the basis of temporal characteristics of neuronal activity of anatomically separated brain regions. On resting-state fMRI studies, the existence of stable and functionally linked restingstate brain networks was shown, that is important in the context of basic mechanisms of neurological disorders. We performed a first resting-state fMRI study in Russia in the group of 10 healthy subjects and revealed a clear default mode network pattern which was consistent with data in published papers. Examining of integrative system of functionally interacting brain regions with the use of resting-state fMRI can provide new insights into large-scale neuronal communication within the human brain.

В последнее время с целью изучения основных сенсорных, эмоциональных и когнитивных процессов в норме и при патологии был предложен новый метод – функциональная магнитно-резонансная томография в состоянии покоя (фМРТп). Он позволяет оценить степень спонтанной коактивации различных центров ЦНС в покое на основе сходства временных характеристик нейрональной активности, выявляемой для анатомически удаленных друг от друга участков головного мозга. При фМРТп-исследованиях показано существование стабильных функционально связанных «сетей покоя» головного мозга, изучение которых перспективно в контексте анализа фундаментальных механизмов развития неврологических заболеваний. Нами впервые в России было проведено фМРТп-исследование в группе из 10 здоровых субъектов и выявлен отчетливый паттерн сети пассивного режима работы головного мозга, согласующийся по своему характеру с данными зарубежных исследований. Исследование с помощью фМРТп интегративной системы функционально взаимодействующих участков головного мозга человека может помочь по-новому взглянуть на широкие нейрональные взаимосвязи в рамках центральной нервной системы.

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