Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector25310.17816/psaic253ReviewsОбзорыUnknownBlood-brain barrier models in vitro: current situation and prospectsМодели гематоэнцефалического барьера in vitro: современное состояние проблемы и перспективыMorgunA. V.МоргунA. В.
Russian Federation
Ximikat-007@yandex.ruKuvachevaN. V.КувачеваН. В.
Russian Federation
Ximikat-007@yandex.ruKоmlevaYu. K.КомлеваЮ. K.
Russian Federation
Ximikat-007@yandex.ruPozhilenkovaE. A.ПожиленковаE. A.
Russian Federation
Ximikat-007@yandex.ruKutishchevaI. A.КутищеваИ. A.
Russian Federation
Ximikat-007@yandex.ruGagarinaE. S.ГагаринаE. С.
Russian Federation
Ximikat-007@yandex.ruTaranushenkoT. E.ТаранушенкоT. E.
Russian Federation
Ximikat-007@yandex.ruOzerskayaA. V.ОзерскаяA. В.
Russian Federation
Ximikat-007@yandex.ruOkunevaO. S.ОкуневаO. С.
Russian Federation
Ximikat-007@yandex.ruSalminaA. B.СалминаАлла Борисовна
Russian Federation
Ximikat-007@yandex.ruKrasnoyarsk State Medical UniversityГБОУ ВПО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России1012201264425102022017Copyright ©; 2012, Morgun A.V., Kuvacheva N.V., Kоmleva Y.K., Pozhilenkova E.A., Kutishcheva I.A., Gagarina E.S., Taranushenko T.E., Ozerskaya A.V., Okuneva O.S., Salmina A.B.Copyright ©; 2012, Morgun A.V., Kuvacheva N.V., Kоmleva Y.K., Pozhilenkova E.A., Kutishcheva I.A., Gagarina E.S., Taranushenko T.E., Ozerskaya A.V., Okuneva O.S., Salmina A.B.2012Morgun A.V., Kuvacheva N.V., Kоmleva Y.K., Pozhilenkova E.A., Kutishcheva I.A., Gagarina E.S., Taranushenko T.E., Ozerskaya A.V., Okuneva O.S., Salmina A.B.Morgun A.V., Kuvacheva N.V., Kоmleva Y.K., Pozhilenkova E.A., Kutishcheva I.A., Gagarina E.S., Taranushenko T.E., Ozerskaya A.V., Okuneva O.S., Salmina A.B.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/253

Current experimental models of the blood-brain barrier (BBB) in vitro used for studying mechanisms of permeability and intercellular communication are discussed in this review. At present, monolayer, multilayer and computer models are in use for the above-mentioned purposes. Primary isolated cells that make up the models in vitro may have brain and non-brain origin. In addition, transplantable cell lines and co-cultured cells could be used for modeling BBB in vitro.

В обзоре рассматриваются существующие экспериментальные модели гематоэнцефалического барьера in vitro, применяемые для исследований проницаемости и межклеточных взаимодействий. В настоящее время для указанных целей применяются монослойные, многослойные и компьютерные модели. Первично выделенные клетки, входящие в состав моделей in vitro, могут быть мозгового и немозгового происхождения. Также используются перевиваемые линии клеток и со-культуры клеток.

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