Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector27110.17816/psaic271ReviewsОбзорыUnknownPolyamines: their role in normal condition and in disorders of the central neural systemsПолиамины: их роль в норме и при патологии центральной нервной системыBerezovT. T.БерезовT. T.
Russian Federation
mgm52@bk.ruMakletsovaM. G.МаклецоваM. Г
Russian Federation
mgm52@bk.ruFedorovaT. N.ФедороваT. Н.
Russian Federation
mgm52@bk.ruResearch Center of Neurology, Russian Academy of Medical SciencesФГБУ «Научный центр неврологии» РАМНDepartment of Biochemistry of the Medical school, People’s Friendship UniversityМедицинский факультет Российского университета дружбы народов1006201262384202022017Copyright ©; 2012, Berezov T.T., Makletsova M.G., Fedorova T.N.Copyright ©; 2012, Berezov T.T., Makletsova M.G., Fedorova T.N.2012Berezov T.T., Makletsova M.G., Fedorova T.N.Berezov T.T., Makletsova M.G., Fedorova T.N.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/271

Along with a well-studied role of polyamines in the regulation of biosynthesis of protein, RNA and DNA, reparative regeneration and oncopathology, the ability of polyamines to act as modulators of neurotransmitter systems in the brain has been shown. There is growing evidence that metabolic abnormalities of polyamines may lead to the development of a number of the central nervous system (CNS) disorders. The study of this problem is important for understanding the molecular basis of pathogenesis and methods of diagnosis of the CNS disorders, as well as for the development of methods for their pharmacological correction on the basis of influence on the polyamine system.

Наряду с хорошо изученной ролью полиаминов в регуляции процессов биосинтеза белка, РНК, ДНК, репаративной регенерации, развитии онкопроцессов, показана способность полиаминов выступать в роли модуляторов нейромедиаторных систем мозга. Существует большое число свидетельств, что нарушения обмена полиаминов могут приводить к развитию ряда патологических состояний центральной нервной системы (ЦНС). Изучение данной проблемы важно для понимания молекулярных основ патогенеза, методов диагностики заболеваний ЦНС, а также для разработки новых способов их фармакологической коррекции на основе воздействия на систему полиаминов.

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