Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector31110.17816/psaic311Original articlesОригинальные статьиUnknownRegulatory T-cells CD4+CD25+Foxр3+ in patients with remitting multiple sclerosisРегуляторные Т-клетки CD4+CD25+Foxр3+ у больных ремитирующим рассеянным склерозомEliseevaD. D.ЕлисееваД. Д.
Russian Federation
delis.82@mail.ruZavalishinI. A.ЗавалишинИ. A.
Russian Federation
delis.82@mail.ruBykovskayaS. N.БыковскаяС. Н.
Russian Federation
delis.82@mail.ruFedorovaT. N.ФедороваT. Н.
Russian Federation
delis.82@mail.ruKarandashovE. N.КарандашовE. Н.
Russian Federation
delis.82@mail.ruTrunovaO. A.ТруноваO. A.
Russian Federation
delis.82@mail.ruResearch Center of Neurology, Russian Academy of Medical SciencesНаучный центр неврологии РАМНRussian State Medical University named after N.I. PirogovРоссийский государственный медицинский университет им. Н.И. Пирогова130620115291303022017Copyright ©; 2011, Eliseeva D.D., Zavalishin I.A., Bykovskaya S.N., Fedorova T.N., Karandashov E.N., Trunova O.A.Copyright ©; 2011, Eliseeva D.D., Zavalishin I.A., Bykovskaya S.N., Fedorova T.N., Karandashov E.N., Trunova O.A.2011Eliseeva D.D., Zavalishin I.A., Bykovskaya S.N., Fedorova T.N., Karandashov E.N., Trunova O.A.Eliseeva D.D., Zavalishin I.A., Bykovskaya S.N., Fedorova T.N., Karandashov E.N., Trunova O.A.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/311

In the maintenance of immunological tolerance a recently discovered population of regulatory T-cells CD4+CD25+Foxp3+ (Treg) plays an important role. These cells have potential in suppressing pathologic immune response observed in various autoimmune diseases, including multiple sclerosis. In the present work, we showed reduction in the number and functional activity of Treg in peripheral blood of patients with multiple sclerosis in the acute stage, as well as increase in Treg content in the disease remission and relation of the Treg content with duration of the autoimmune process and the degree of disability of patients.

В процессах поддержания иммунологической толерантности важная роль принадлежит недавно открытой популяции регуляторных Т-клеток CD4+CD25+Foxр3+ (Трег). Эти клетки обладают огромным потенциалом в подавлении патологического иммунного ответа, наблюдающегося при различных аутоиммунных заболеваниях, в том числе при рассеянном склерозе. В настоящей работе нами показано снижение числа и функциональной активности Трег в периферической крови больных рассеянным склерозом в стадии обострения, увеличение их количества при ремиссии заболевания, связь длительности аутоиммунного процесса и степени инвалидизации больных с содержанием Трег.

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