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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">316</article-id><article-id pub-id-type="doi">10.17816/psaic316</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Technologies</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Технологии</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Functional Magnefic Resonance Imaging</article-title><trans-title-group xml:lang="ru"><trans-title>Функциональная магнитно-резонансная томография</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9396-6063</contrib-id><name-alternatives><name xml:lang="en"><surname>Kremneva</surname><given-names>Elena I.</given-names></name><name xml:lang="ru"><surname>Кремнева</surname><given-names>Елена Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), senior researcher, Radiology department</p></bio><bio xml:lang="ru"><p>к.м.н., с.н.с. отд. нейровизуализации</p></bio><email>moomin10j@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5539-245X</contrib-id><name-alternatives><name xml:lang="en"><surname>Konovalov</surname><given-names>Rodion N.</given-names></name><name xml:lang="ru"><surname>Коновалов</surname><given-names>Родион Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), senior researcher, Neuroradiology department</p></bio><bio xml:lang="ru"><p>к.м.н., с.н.с. отд. лучевой диагностики</p></bio><email>moomin10j@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3820-4554</contrib-id><name-alternatives><name xml:lang="en"><surname>Krotenkova</surname><given-names>Marina V.</given-names></name><name xml:lang="ru"><surname>Кротенкова</surname><given-names>Марина Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Head, Radiology department</p></bio><bio xml:lang="ru"><p>д.м.н., зав. отд. нейровизуализации</p></bio><email>moomin10j@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Center of Neurology</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Научный центр неврологии»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-03-13" publication-format="electronic"><day>13</day><month>03</month><year>2011</year></pub-date><volume>5</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>30</fpage><lpage>38</lpage><history><date date-type="received" iso-8601-date="2017-02-03"><day>03</day><month>02</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Kremneva E.I., Konovalov R.N., Krotenkova M.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, Kremneva E.I., Konovalov R.N., Krotenkova M.V.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Kremneva E.I., Konovalov R.N., Krotenkova M.V.</copyright-holder><copyright-holder xml:lang="ru">Kremneva E.I., Konovalov R.N., Krotenkova M.V.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/316">https://annaly-nevrologii.com/pathID/article/view/316</self-uri><abstract xml:lang="en"><p> </p><p>Since the early 1990s, fMRI has come to dominate the brain mapping field due to its relatively low invasiveness, absence of radiation exposure, and relatively wide availability. It measures the hemodynamic response related to neural activity in the brain (BOLD-effect). During planning fMRI experiment it is important to take into account equipment (MRI scan, devices for the stimuli presentation), experimental design and post processing. The last one includes several important steps, such as realignment, co-registration, normalization, smoothing. Nowadays fMRI is widely used not only in research field, especially for cognitive studies, but in clinical practice. However investigator should always remember some limitations and controversies, especially in patients with various nosological forms. It is also important to draw many specialists in experiment and its interpretation — neuroradiologists, MR-physicists, clinicians, psychologists, etc. — while fMRI is multidisciplinary methodic.</p>  <p> </p> <p> </p></abstract><trans-abstract xml:lang="ru"><p>Начиная с 90-х гг. XX в., функциональная магнитно-резонансная томография (фМРТ) является одной из ведущих методик картирования функциональных зон головного мозга в виду своей неинвазивности, отсутствия лучевой нагрузки и относительно широкой распространенности. Суть данной методики заключается в измерении гемодинамических изменений в ответ на нейрональную активность (BOLD-эффект). Для успеха фМРТ-эксперимента необходимо: наличие соответствующего технического обеспечения (высокопольный МР-томограф, специальное оборудование для выполнения заданий), разработка оптимального дизайна исследования, постобработка полученных данных. В настоящее время методика применяется не только в научных целях, но и в практической медицине. Однако нужно всегда помнить о некоторых ограничениях и противопоказаниях, особенно при проведении фМРТ у пациентов с различной патологией. Для правильного планирования исследования и интерпретации его результатов необходимо привлечение различных специалистов: нейрорентгенологов, биофизиков, неврологов, психологов, поскольку фМРТ является мультидисциплинарной методикой.</p></trans-abstract><kwd-group xml:lang="en"><kwd>fMRI</kwd><kwd>BOLD-contrast</kwd><kwd>paradigm</kwd><kwd>post processing</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>фМРТ</kwd><kwd>BOLD-контраст</kwd><kwd>дизайн исследования</kwd><kwd>постобработка</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ashburner J., Friston K. Multimodal image coregistration and partitioning – a unified framework. NeuroImage 1997; 6 (3): 209–217.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Brian N. Pasley, Ralph D. Freeman. Neurovascular coupling. 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