Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector32710.17816/psaic327Original articlesОригинальные статьиUnknownMechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxicationМеханизмы развития атрофии скелетных мышц при хронической алкогольной интоксикацииKazantsevaYu. V.КазанцеваЮ. В.
Russian Federation
zinovyevaolga@yandex.ruMaslovaG. V.МасловаГ. В.
Russian Federation
zinovyevaolga@yandex.ruLysenkoE. A.ЛысенкоE. A.
Russian Federation
zinovyevaolga@yandex.ruZinovyevaO. E.ЗиновьеваO. E.
Russian Federation
zinovyevaolga@yandex.ruShenkmanB. S.ШенкманБ. С.
Russian Federation
zinovyevaolga@yandex.ruYakhnoN. N.ЯхноН. Н.
Russian Federation
zinovyevaolga@yandex.ru1st Moscow State Medical University named after I.M. SechenovПервый Московский государственный медицинский университет им. И.М. СеченоваInstitute of Medico-Biological Problems, Russian Academy of SciencesГосударственный научный центр РФ — Институт медико-биологических проблем РАН1312201044151903022017Copyright ©; 2010, Kazantseva Y.V., Maslova G.V., Lysenko E.A., Zinovyeva O.E., Shenkman B.S., Yakhno N.N.Copyright ©; 2010, Kazantseva Y.V., Maslova G.V., Lysenko E.A., Zinovyeva O.E., Shenkman B.S., Yakhno N.N.2010Kazantseva Y.V., Maslova G.V., Lysenko E.A., Zinovyeva O.E., Shenkman B.S., Yakhno N.N.Kazantseva Y.V., Maslova G.V., Lysenko E.A., Zinovyeva O.E., Shenkman B.S., Yakhno N.N.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/327

Chronic alcohol myopathy (CAM) is one of frequent manifestations of the alcoholic disease, but its pathogenesis remains to be elucidated. Main mechanism of the CAM development is suggested to be abnormalities of protein synthesis in muscle fibers. A complex clinical, morphological and biochemical investigation of 38 patients with chronic alcohol intoxication was performed. Clinical manifestations of skeletal muscle damage corresponded to severity of the atrophic process assessed by histological studies of muscle biopsies. Disturbances of main stages of protein synthesis both on intracellular and on systemic regulatory level was revealed.

Хроническая алкогольная миопатия (ХАМ) — одно из частых проявлений алкогольной болезни. Патогенез ее до конца не изучен. Предполагают, что основным механизмом развития ХАМ является нарушение процессов синтеза белка в мышечных волокнах. Проведено комплексное клиническое, морфологическое и биохимическое исследование 38 пациентов с хронической алкогольной интоксикацией. Клинические проявления поражения скелетных мышц соответствовали выраженности атрофического процесса, определяемого по данным гистологического исследования мышечных биоптатов. Выявлено нарушение основных звеньев синтеза белка, как на внутриклеточном, так и на системном уровне регуляции.

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