Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector33110.17816/psaic331ReviewsОбзорыUnknownNeurotransmitter structure and functional role of cerebellumНейротрансмиттерная организация и функциональное значение мозжечкаBarkhatovaV. P.БархатоваВалентина Павловна
Russian Federation
platonova@neurology.ruResearch Center of Neurology, Russian Academy of Medical SciencesНаучный центр неврологии РАМН1309201043444903022017Copyright ©; 2010, Barkhatova V.P.Copyright ©; 2010, Barkhatova V.P.2010Barkhatova V.P.Barkhatova V.P.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/331

The review summarizes modern concepts concerning functional role and neurotransmitter organization of the cerebellum. The results of recent studies demonstrated that the cerebellum might be involved not only in motor control, but also in regulation of cognitive functions, affective and behaviour reactions, development of emotional-personality and mental disturbances, as well as in modulation of cerebral blood flow and metabolism. Futher studies of the functional role of different cerebellar neurotransmitter systems and their mechanisms of interaction are very important for understanding the pathogenesis and for the development of approaches to the treatment and prevention of the cerebellum-related motor and non-motor disorders.

В обзоре обобщены современные представления о нейротрансмиттерной организации и функциональном значении мозжечка. Как показали последние исследования, мозжечок участвует в контроле не только двигательных, но и когнитивных функций, аффективных и поведенческих реакций, динамике эмоционально-личностных и психических изменений, а также в регуляции церебрального кровотока и метаболизма. Дальнейшее изучение механизмов взаимодействия и функциональной роли различных нейротрансмиттерных систем мозжечка имеет большое значение для понимания патогенеза и разработки подходов к лечению и профилактике связанных с его патологией двигательных и недвигательных нарушений.

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