Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector39010.17816/psaic390Original articlesОригинальные статьиUnknownUltrastructure of synapses of human cerebral cortex in the old ageУльтраструктура синапсов коры большого мозга человека в старческом возрастеBogolepovN. N.БоголеповНиколай Николаевич
Russian Federation
platonova@neurology.ruResearch Center of Neurology, Russian Academy of Medical SciencesНаучный центр неврологии РАМН1412200824222707022017Copyright ©; 2008, Bogolepov N.N.Copyright ©; 2008, Bogolepov N.N.2008Bogolepov N.N.Bogolepov N.N.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/390

In the present electron-microscopic study, changes of ultrastructure of synapses in the sensory-motor and frontal cerebral cortex in humans of old age are demonstrated. Abnormalities of distribution of synaptic vesicles in the presynaptic ending and changes of mechanisms of their rapprochement and attachment to the presynaptic membrane were found. Analysis of the obtained results suggests that disturbed interaction between synaptic vesicles and presynaptic membrane represents a stage preceding the destruction and disappearance of the synapse

В настоящем электронно-микроскопическом исследовании показаны изменения ультраструктуры синапсов сенсомоторной и лобной областей коры большого мозга человека в старческом возрасте. Выявлены изменения в распределении синаптических пузырьков в пресинаптическом отростке и механизмах их сближения и стыковки с пресинаптической мембраной. Анализ полученных результатов свидетельствует о том, что нарушение взаимодействия синаптических пузырьков и пресинаптической мембраны является стадией, предшествующей деструкции и исчезновению синапса.

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