Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector39510.17816/psaic395ReviewsОбзорыUnknownNeuron-astroglial interactions in dysregulation of energy metabolism in perinatal ischemic brain damageРоль нейрон-астроглиальных взаимодействий в дизрегуляции энергетического метаболизма при ишемическом перинатальном поражении головного мозгаSalminaAlla B.СалминаАлла Борисовна
Russian Federation
s.v.proc.58@mail.ruOkunevaS. O.ОкуневаС. O.
Russian Federation
s.v.proc.58@mail.ruTaranushenkoT. E.ТаранушенкоT. E.
Russian Federation
s.v.proc.58@mail.ruFursovA. A.ФурсовA. A.
Russian Federation
s.v.proc.58@mail.ruProkopenkoSemen V.ПрокопенкоСемен В.
Russian Federation
s.v.proc.58@mail.ruMikhutkinaS. V.МихуткинаС. В.
Russian Federation
s.v.proc.58@mail.ruMalinovskayaN. A.МалиновскаяН. A.
Russian Federation
s.v.proc.58@mail.ruTagaevaG. A.ТагаеваГ. A.
Russian Federation
s.v.proc.58@mail.ruVoyno-Yasenetsky Krasnoyarsk State Medical UniversityФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого»Krasnoyarsk State Medical AcademyФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого»Krasnoyarsk State Medical UniversityФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого»Krasnoyarsk State Medical University named after Prof. V.F. Voyno-YasenetskyФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого»1409200823445107022017Copyright ©; 2008, Salmina A.B., Okuneva S.O., Taranushenko T.E., Fursov A.A., Prokopenko S.V., Mikhutkina S.V., Malinovskaya N.A., Tagaeva G.A.Copyright ©; 2008, Salmina A.B., Okuneva S.O., Taranushenko T.E., Fursov A.A., Prokopenko S.V., Mikhutkina S.V., Malinovskaya N.A., Tagaeva G.A.2008Salmina A.B., Okuneva S.O., Taranushenko T.E., Fursov A.A., Prokopenko S.V., Mikhutkina S.V., Malinovskaya N.A., Tagaeva G.A.Salmina A.B., Okuneva S.O., Taranushenko T.E., Fursov A.A., Prokopenko S.V., Mikhutkina S.V., Malinovskaya N.A., Tagaeva G.A.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/395

Presented is a review of the literature on the problem of hypoxic-ischemic perinatal brain damage in the context of alterations of astroglial regulation of neuronal energy metabolism and mechanisms of excitotoxicity. Characteristics of energy metabolism in the developing brain responsible for specificity of its damage in perinatal period, as well as cell and molecular mechanisms of disturbances of neuron-astrocyte coupling controlling regulation of neuroplasticity are discussed.

Представлен обзор литературы по проблеме гипоксически-ишемического перинатального поражения головного мозга с позиции нарушения астро-глиальной регуляции энергетического метаболизма нейронов и механизмов эксайтотоксичности. Детально обсуждаются особенности энергетического обмена в развивающемся мозге, обусловливающие специфику его поражения в перинатальном периоде, а также клеточно-молекулярные механизмы нарушения нейрон-астроглиальных взаимоотношений, контролирующих регуляцию нейропластичности.

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