Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector41310.17816/psaic413Original articlesОригинальные статьиUnknownThe endocannabinoid signaling system and new experimental approaches to the treatment of movement disordersЭндоканнабиноидная сигнальная система и новые экспериментальные подходы к лечению двигательных нарушенийBarkhatovaV. P.БархатоваВалентина Павловна
Russian Federation
platonova@neurology.ruResearch Center of Neurology, Russian Academy of Medical SciencesНаучный центр неврологии РАМН1403200821283107022017Copyright ©; 2008, Barkhatova V.P.Copyright ©; 2008, Barkhatova V.P.2008Barkhatova V.P.Barkhatova V.P.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/413

Reviewed are modern concepts concerning physiological role and mechanisms of brain functioning of the endocannabinoid signaling system comprising cannabinoid receptors, endocannabinoids and proteins participating in their synthesis, transport and degradation. The results of recent experimental studies showing an important role of the endocannabinoid system in motor control and mechanisms of movement disorders in multiple sclerosis, Parkinson’s disease and Huntington’s chorea are presented. In this context, investigation of possibilities of pharmacological correction of the endocannabinoid transmission should be considered as a novel and important field in experimental neurology with significant therapeutic potential.

Обобщены современные представления о физиологической роли и механизмах функционирования в мозге эндоканнабиноидной сигнальной системы, включающей каннабиноидные рецепторы, эндоканнабиноиды и белки, участвующие в их синтезе, транспорте и метаболизме. Представлены результаты последних экспериментальных работ, свидетельствующие о важной роли эндоканнабиноидной системы в регуляции двигательных функций и развитии двигательных нарушений при рассеянном склерозе, паркинсонизме и хорее Гентингтона. В связи с этим изучение возможностей фармакологической коррекции эндоканнабиноидной трансмиссии следует считать новым и важным направлением в экспериментальной неврологии, имеющим значительный терапевтический потенциал.

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