Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector46310.17816/ACEN.2017.1.6169ReviewsОбзорыUnknownSmall fiber neuropathyНевропатия тонких волоконhttps://orcid.org/0000-0003-3956-6362SuponevaNatalya A.СупоневаНаталья Александровна
Russian Federation

D. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, principal researcher, Department of neurorehabilitation and physiotherapy

д.м.н., проф., член-корреспондент РАН, г.н.с. отд. нейрореабилитации и физиотерапии

lagoda.d@neurology.ruBelovaNatalia V.БеловаНаталья Вячеславовна
Russian Federation
lagoda.d@neurology.ruZaitsevaNatalia I.ЗайцеваНаталья И.
Russian Federation
lagoda.d@neurology.ruhttps://orcid.org/0000-0002-5826-9112YusupovaDjamilya G.ЮсуповаДжамиля Гереевна
Russian Federation

neurologist, junior researcher, Department of neurorehabilitation and physiotherapy

врач-невролог, н.с. отд. нейрореабилитации и физиотерапии

lagoda.d@neurology.ruhttps://orcid.org/0000-0002-9267-8315LagodaDmitry Yu.ЛагодаДмитрий Юрьевич
Russian Federation

junior researcher, Department of neurorehabilitation and physiotherapy

м.н.с. отд. нейрореабилитации и физиотерапии

lagoda.d@neurology.ruKorepinaOlga S.КорепинаОльга С.
Russian Federation
lagoda.d@neurology.ruhttps://orcid.org/0000-0002-6338-0392PiradovMikhail A.ПирадовМихаил Александрович
Russian Federation

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

д.м.н., проф., академик РАН, директор

lagoda.d@neurology.ruResearch Center of NeurologyФГБНУ «Научный центр неврологии»Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»12052017111737920042017Copyright ©; 2017, Suponeva N.A., Belova N.V., Zaitseva N.I., Yusupova D.G., Lagoda D.Y., Korepina O.S., Piradov M.A.Copyright ©; 2017, Suponeva N.A., Belova N.V., Zaitseva N.I., Yusupova D.G., Lagoda D.Y., Korepina O.S., Piradov M.A.2017Suponeva N.A., Belova N.V., Zaitseva N.I., Yusupova D.G., Lagoda D.Y., Korepina O.S., Piradov M.A.Suponeva N.A., Belova N.V., Zaitseva N.I., Yusupova D.G., Lagoda D.Y., Korepina O.S., Piradov M.A.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/463

Despite the fact that small fiber neuropathy (SFN) has already been studied for 30 years, it remains one of the most mysterious diseases that are extremely difficult to diagnose and cure. The prevalence of SFN is 52.95 per 100,000 population; diabetes mellitus is considered to be the most frequent cause of this disease. Chronic neuropathic pain syndrome, temperature sensation abnormalities, and vegetative disorders develop as a result of damage to fine myelinated Аδ- and unmyelinated C fibers. The disease mainly spreads in the upward direction: from feet to the proximal body parts and arms; primary axonal damage takes place. Although SFN is believed to be one of the most “benign” neuropathy types as it does not affect the large sensory and motor fibers, it significantly decreases patients’ quality of life.

Невропатия тонких волокон (НТВ), несмотря на тридцатилетнюю историю изучения, остается одним из самых загадочных заболеваний, которые с трудом поддаются диагностике и лечению. Распространенность НТВ составляет 52,95 на 100 000 населения, наиболее частой причиной ее развития считается сахарный диабет. В результате повреждения тонких миелинизированных Аδ- и немиелинизированных С-волокон формируются хронический невропатический болевой синдром, расстройства температурной чувствительности, вегетативные нарушения. Заболевание в основном развивается по «восходящему типу», распространяясь со стоп на проксимальные отделы и руки, тип поражения нервов – первично аксональный. Несмотря на то, что НТВ считается одной из самых «доброкачественных» невропатий, т.к. не вовлекает крупные чувствительные и двигательные волокна, качество жизни пациентов заметно снижается.

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