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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">501</article-id><article-id pub-id-type="doi">10.17816/ACEN.2017.4.7</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical analysis</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинический разбор</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">PET-CT in early detection of Alzheimer’s disease: а case report</article-title><trans-title-group xml:lang="ru"><trans-title>Клинический случай применения ПЭТ/КТ в ранней диагностике болезни Альцгеймера</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Prokopenko</surname><given-names>Semen V.</given-names></name><name xml:lang="ru"><surname>Прокопенко</surname><given-names>Семен В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Barankin</surname><given-names>Boris V.</given-names></name><name xml:lang="ru"><surname>Баранкин</surname><given-names>Борис В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mar'ina</surname><given-names>Natal'ya М.</given-names></name><name xml:lang="ru"><surname>Марьина</surname><given-names>Наталья М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mozheyko</surname><given-names>Еlena Y.</given-names></name><name xml:lang="ru"><surname>Можейко</surname><given-names>Елена Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bezdenezhnykh</surname><given-names>Аnna F.</given-names></name><name xml:lang="ru"><surname>Безденежных</surname><given-names>Анна Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Koryagina</surname><given-names>Tat'yana D.</given-names></name><name xml:lang="ru"><surname>Корягина</surname><given-names>Татьяна Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chanchikova</surname><given-names>Natal'ya G.</given-names></name><name xml:lang="ru"><surname>Чанчикова</surname><given-names>Наталья Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tokarev</surname><given-names>Nikolay А.</given-names></name><name xml:lang="ru"><surname>Токарев</surname><given-names>Николай А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karlova</surname><given-names>Еlena А.</given-names></name><name xml:lang="ru"><surname>Карлова</surname><given-names>Елена А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ozerskaya</surname><given-names>Аnastasiya V.</given-names></name><name xml:lang="ru"><surname>Озерская</surname><given-names>Анастасия В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Badrin</surname><given-names>Еvgeniy А.</given-names></name><name xml:lang="ru"><surname>Бадрин</surname><given-names>Евгений А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Belugin</surname><given-names>Кirill V.</given-names></name><name xml:lang="ru"><surname>Белугин</surname><given-names>Кирилл В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Savel'eva</surname><given-names>Аnastasiya А.</given-names></name><name xml:lang="ru"><surname>Савельева</surname><given-names>Анастасия А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shepelevich</surname><given-names>Nikolay V.</given-names></name><name xml:lang="ru"><surname>Шепелевич</surname><given-names>Николай В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>t6868@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal Siberian Research Clinical Center</institution></aff><aff><institution xml:lang="ru">ФГБУ «Федеральный Сибирский научно-клинический центр Федерального медико-биологического агентства»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-12-27" publication-format="electronic"><day>27</day><month>12</month><year>2017</year></pub-date><volume>11</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>65</fpage><lpage>70</lpage><history><date date-type="received" iso-8601-date="2017-12-24"><day>24</day><month>12</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Prokopenko S.V., Barankin B.V., Mar'ina N.М., Mozheyko Е.Y., Bezdenezhnykh А.F., Koryagina T.D., Chanchikova N.G., Tokarev N.А., karlova Е.А., Ozerskaya А.V., Badrin Е.А., Belugin К.V., Savel'eva А.А., Shepelevich N.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Prokopenko S.V., Barankin B.V., Mar'ina N.М., Mozheyko Е.Y., Bezdenezhnykh А.F., Koryagina T.D., Chanchikova N.G., Tokarev N.А., karlova Е.А., Ozerskaya А.V., Badrin Е.А., Belugin К.V., Savel'eva А.А., Shepelevich N.V.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Prokopenko S.V., Barankin B.V., Mar'ina N.М., Mozheyko Е.Y., Bezdenezhnykh А.F., Koryagina T.D., Chanchikova N.G., Tokarev N.А., karlova Е.А., Ozerskaya А.V., Badrin Е.А., Belugin К.V., Savel'eva А.А., Shepelevich N.V.</copyright-holder><copyright-holder xml:lang="ru">Prokopenko S.V., Barankin B.V., Mar'ina N.М., Mozheyko Е.Y., Bezdenezhnykh А.F., Koryagina T.D., Chanchikova N.G., Tokarev N.А., karlova Е.А., Ozerskaya А.V., Badrin Е.А., Belugin К.V., Savel'eva А.А., Shepelevich N.V.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/501">https://annaly-nevrologii.com/pathID/article/view/501</self-uri><abstract xml:lang="en"><p>The article describes a clinical case of a female Alzheimer disease patient at an early stage of the neurodegenerative process. The patient did not have any complaints. She was taken to the neuropsychologist’s by her husband that was concerned because of the patient's family history (his mother-in-law suffered of Alzheimer's disease) and the emergence of some memory problems in his wife. The diagnosis was suspected based on the results of neuropsychological evaluation of cognitive functions which corresponded to mild cognitive impairment. To confirm the presence of a neurodegenerative disease brain positron-emission tomography with F-18 fluorodesoxyglucose (FDG) was performed. Hypometabolism of the imaging agent was detected in the temporal and parietal lobes cortex, in the association cortex of the left temporal and the right occipital lobes, and in the posterior part of the left cyngulate gyrus. This findings correlated with the data of the patient’s cognitive evaluation and thus provided the nosological diagnosis at an early stage of the disease. </p></abstract><trans-abstract xml:lang="ru"><p>В статье представлено описание клинического случая пациентки с болезнью Альцгеймера на ранней стадии нейродегенеративного процесса. Больная жалоб не предъявляла; на прием нейропсихолога ее привел муж, которого насторожил семейный анамнез (теща страдала болезнью Альцгеймера) и некоторая забывчивость пациентки. На первом этапе диагноз был заподозрен в результате нейропсихологического исследования когнитивных функций, оценка которых соответствовала умеренному когнитивному расстройству. В дальнейшем с целью верификации нейродегенеративного заболевания была проведена позитронно-эмиссионная томография головного мозга с [18F]-фтордезоксиглюкозой. Выявлен гипометаболизм радиофармпрепарата в коре височных и теменных долей, в ассоциативной коре левой лобной и правой затылочной долей, в задней части левой поясной извилины, что коррелировало с данными когнитивного статуса и позволило выставить нозологический диагноз на ранней стадии заболевания. </p></trans-abstract><kwd-group xml:lang="en"><kwd>Alzheimer's disease</kwd><kwd>early detection</kwd><kwd>positron-emission tomography</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>болезнь Альцгеймера</kwd><kwd>ранняя диагностика</kwd><kwd>позитронно-эмиссионная томография</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Dierckx R.A.J.O., Otte A., de Vries E.F.J., Leenders K.L. (Eds.) PET and SPECT in Neurology. Berlin, Heidelberg: Springer-Verlag; 2014; 1074 p.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Luriya A.R. 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