Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector50210.17816/ACEN.2017.4.8ReviewsОбзорыUnknownIschemic stroke and inherited thrombophiliasИшемический инсульт и наследственные тромбофилические состоянияPizovaNatalia V.ПизоваНаталья Вячеславовна
Russian Federation
pizova@yandex.ruYaroslavl' State Medical UniversityФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России27122017114717924122017Copyright ©; 2017, Pizova N.V.Copyright ©; 2017, Pizova N.V.2017Pizova N.V.Pizova N.V.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/502

In this review the impact of the most common thrombophilias on the risk of ischemic stroke and atherothrombosis is thoroughly analyzed. The functional role of different β-fibrinogen genotypes was reviewed and their correlations with ischemic cerebrovascular diseases, brachiocephalic artery atherosclerosis and arterial hypertension are evaluated. In addition, associations of stroke with key genetic factors such as the Leyden mutation (factor V), mutations in the genes of prothrombin, PAI-1 (plasminogen activator inhibitor), glycoprotein IIIa, etc. are assessed. Results of the authors’ own works on the occurrence of various inherited thrombophilias in a group of 43 patients with ischemic stroke of undefined origin are presented.

В обзоре представлен детальный анализ роли наиболее распространенных форм тромбофилий в формировании риска ишемического инсульта и атеротромбоза в популяции. Рассмотрено функциональное значение различных генотипов β-фибриногена в их взаимосвязи с ишемическими нарушениями мозгового кровообращения, атеросклеротическим поражением брахиоцефальных артерий, артериальной гипертензией. Представлены ассоциации между развитием инсульта и такими ключевыми генетическими факторами, как Лейденская мутация (фактор V), мутации в генах протромбина, ингибитора активатора плазминогена 1 типа, гликопротеина IIIa и др. Представлены собственные данные, касающиеся распространенности различных вариантов наследственных тромбофилий в группе из 43 пациентов с ишемическим инсультом неуточненного генеза.

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