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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">514</article-id><article-id pub-id-type="doi">10.25692/ACEN.2018.1.8</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Technologies</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Технологии</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Multimodal studies of the human brain using functional magnetic resonance imaging and magnetic resonance spectroscopy</article-title><trans-title-group xml:lang="ru"><trans-title>Мультимодальные исследования головного мозга человека с использованием функциональной магнитно-резонансной томографии и магнитно-резонансной спектроскопии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ublinskiy</surname><given-names>Maksim V.</given-names></name><name xml:lang="ru"><surname>Ублинский</surname><given-names>Максим В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maxublinsk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Manzhurtsev</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Манжурцев</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maxublinsk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Men'shchikov</surname><given-names>P. E.</given-names></name><name xml:lang="ru"><surname>Меньщиков</surname><given-names>П. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maxublinsk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Akhadov</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Ахадов</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maxublinsk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Semenova</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Семенова</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maxublinsk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Institute of Emergency Pediatric Surgery and Traumatology</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт неотложной детской хирургии и травматологии</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-03-28" publication-format="electronic"><day>28</day><month>03</month><year>2018</year></pub-date><volume>12</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>54</fpage><lpage>60</lpage><history><date date-type="received" iso-8601-date="2018-03-28"><day>28</day><month>03</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Ublinskiy M.V., Manzhurtsev A.V., Men'shchikov P.E., Akhadov T.A., Semenova N.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Ublinskiy M.V., Manzhurtsev A.V., Men'shchikov P.E., Akhadov T.A., Semenova N.A.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Ublinskiy M.V., Manzhurtsev A.V., Men'shchikov P.E., Akhadov T.A., Semenova N.A.</copyright-holder><copyright-holder xml:lang="ru">Ublinskiy M.V., Manzhurtsev A.V., Men'shchikov P.E., Akhadov T.A., Semenova N.A.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/514">https://annaly-nevrologii.com/pathID/article/view/514</self-uri><abstract xml:lang="en"><p><bold>Abstract </bold></p> <p>Studying the brain structure and function in health and disease is one of the most important and intensively developing fields of neuroscience in the new century. Nowdays, in vivo studies of brain structure, metabolism, blood flow and function are mostly performed using safe imaging technologies not requiring ionizing radiation and based on magnetic resonance imaging (MRI). In this review, the detailed description of the principles of commonly used techniques that provide high-quality information about the brain, such as functional MRI (fMRI) and magnetic resonance spectroscopy (MRS), is presented. The potential and advantages of these methods including their use in combination with other imaging techniques (MR-tractography etc.) are outlined. The authors believe that combining all MRI options in one study may produce a complex approach for exploring physical-chemical mechanisms underlying brain function which may be of value for basic and applied research.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Резюме</bold></p> <p>Исследование структурно-функциональной организации головного мозга в норме и при патологии является одним из приоритетных и интенсивно развивающихся направлений нейронауки в новом столетии. Прижизненные исследования структуры, метаболизма, кровотока, функций головного мозга в настоящее время базируются, главным образом, на биологически безопасных, не связанные с ионизирующим излучением технологиях визуализации, основанных на магнитно-резонансной томографии (МРТ). В обзоре представлено подробное описание основ таких высокоинформативных методик, занявших прочное место в современном исследовательском арсенале, как функциональная МРТ (фМРТ) и магнитно-резонансная спектроскопия (МРС). Представлены возможности и преимущества этих мето<ext-link/>дик, в том числе при их совместном применении с другими нейровизуализационными технологиями (МР-трактография и др.). Авторы убеждены, что совместное применение всех возможностей МРТ в одном исследовании позволит создать комплексный подход к изучению физико-химических механизмов, лежащих в основе функционирования мозга, что имеет как фундаментальное, так и прикладное значение. </p></trans-abstract><kwd-group xml:lang="en"><kwd>Brain magnetic resonance imaging</kwd><kwd>functional MRI</kwd><kwd>MR-spectroscopy</kwd><kwd>multimodal imaging</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>магнитно-резонансная томография головного мозга</kwd><kwd>функциональная МРТ</kwd><kwd>МР-спектроскопия</kwd><kwd>мультимодальные исследования</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Graham G.D., Kalvach P., Blamire A.M. et al. 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