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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">539</article-id><article-id pub-id-type="doi">10.25692/ACEN.2018.3.9</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Technologies</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Технологии</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Optical coherent tomography capabilities in the diagnosis of demyelinating diseases of the central nervous system</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности оптической когерентной томографии в диагностике демиелинизирующих заболеваний центральной нервной системы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Polekhina</surname><given-names>Natalia V.</given-names></name><name xml:lang="ru"><surname>Полехина</surname><given-names>Наталья Вадимовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>natalie.polekhina@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Surnina</surname><given-names>Zoya V.</given-names></name><name xml:lang="ru"><surname>Сурина</surname><given-names>Зоя Васильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>natalie.polekhina@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>Maria N.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>Мария Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>natalie.polekhina@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Center of Neurology</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Научный центр неврологии»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research Institute of Eye Diseases</institution></aff><aff><institution xml:lang="ru">ФГБНУ «НИИ глазных болезней»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-10-05" publication-format="electronic"><day>05</day><month>10</month><year>2018</year></pub-date><volume>12</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>69</fpage><lpage>74</lpage><history><date date-type="received" iso-8601-date="2018-10-09"><day>09</day><month>10</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Polekhina N.V., Surnina Z.V., Zakharova M.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Polekhina N.V., Surnina Z.V., Zakharova M.N.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Polekhina N.V., Surnina Z.V., Zakharova M.N.</copyright-holder><copyright-holder xml:lang="ru">Polekhina N.V., Surnina Z.V., Zakharova M.N.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/539">https://annaly-nevrologii.com/pathID/article/view/539</self-uri><abstract xml:lang="en"><p>Optical coherence tomography (OCT) is a non-invasive technique routinely used for obtaining in vivo transverse images of tissues. In the field of neurology, OCT is used to assess retinal changes in various diseases, including multiple sclerosis, opticomyelitis, and opticomyelitis-associated disorders. In these demyelinating diseases, the pathological process involves not only the optic nerve itself, but also the retinal ganglion cells and their axons, the so-called retinal ganglionic complex, as well as the retinal nerve fiber layer. In the last decade, OCT as the method capable of assessing changes in the above-mentioned retinal layers has been applied as a highly sensitive technology for estimation of neurodegenerative process. The article discusses the possible use of OCT for differential diagnosis of demyelinating diseases of the central nervous system, as well as its application as a method for monitoring involvement of the nervous tissue in demyelinating diseases<italic>.</italic></p></abstract><trans-abstract xml:lang="ru"><p>Оптическая когерентная томография (ОКТ) – неинвазивный метод исследования для получения поперечных изображений тканей in vivo. В неврологии ОКТ используется для оценки изменений сетчатки при различных заболеваниях, в том числе при рассеянном склерозе, оптикомиелите и оптикомиелит-ассоциированных расстройствах. При этих демиелинизирующих заболеваниях в патологический процесс вовлекается не только сам зрительный нерв, но и ганглиозные клетки сетчатки и их аксоны, – так называемый ганглиозный комплекс сетчатки, а также слой нервных волокон сетчатки. В последнее десятилетие ОКТ, при помощи которой можно оценить изменения в указанных слоях сетчатки, стала использоваться как высокочувствительная технология для оценки нейродегенерации. В статье обсуждается возможность применения ОКТ для дифференциальной диагностики демиелинизирующих заболеваний центральной нервной системы, а также в качестве метода мониторинга повреждения нервной ткани при демиелинизирующих заболеваниях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>opticomelitis</kwd><kwd>opticomielitis-associated disorders</kwd><kwd>optical coherence tomography</kwd><kwd>neurodegeneration</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>оптикомиелит</kwd><kwd>оптикомиелит-ассоциированные расстройства</kwd><kwd>оптическая когерентная томография</kwd><kwd>нейродегенерация</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Lumbroso B., Rispoli M. OKT setchatki. Metod analiza i interpretatsii [OCT of the retina. Method of analysis and interpretation]. V.V. Neroev, O.V. Zaitseva (eds.). Moscow: Aprel’; 2012. 83 р. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Ламброзо Б., Рисполи М. ОКТ сетчатки. Метод анализа и интерпретации / Под ред. В.В. Нероева, О.В. Зайцевой. М.: Апрель; 2012. 83 c.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Saidha S., Al-Louzi O., Ratchford J. et al. Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study. Ann Neurol 2015; 78: 801–813. DOI: 10.1002/ana.24487. PMID: 26190464.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Caruana P., Davies M., Weatherby S. et al. Correlation of MRI lesions with visual psychophysical deficit in secondary progressive multiple sclerosis. Brain 2000; 123: 1471-1480. PMID: 10869058.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Noval S., Contreras I., Muñoz S. et al. Optical coherence tomography in multiple sclerosis and neuromyelitis optica: an update. Mult Scler Int 2011; 2011: 472790. DOI: 10.1155/2011/472790. PMID: 22096638.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Parisi V., Manni G., Spadaro M. et al. Correlation between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophthalmol Vis Sci 1999; 40: 2520–2527. PMID: 10509645.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>McDonald W., Barnes D. The ocular manifestations of multiple sclerosis. 1. Abnormalities of the afferent visual system. J Neurol Neurosurg Psychiatry 1992; 55: 747–752. PMID: 1402963.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>La Morgia C., Barboni P., Rizzo G. et al. Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern? Eur J Neurol 2013; 20: 198–201. DOI: 10.1111/j.1468-1331.2012.03701.x. PMID: 22436028.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>de Seze J., Blanc F., Jeanjean L. et al. Optical coherence tomography in neuromyelitis optica. Arch Neurol 2008; 65: 920–923. DOI: 10.1001/archneur.65.7.920. PMID: 18625858.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lennon V., Wingerchuk D., Kryzer T. et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004; 364: 2106–2112. DOI: 10.1016/S0140-6736(04)17551-X. PMID: 15589308.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Naismith R., Tutlam N., Xu J. et al. Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis. Neurology 2009; 72: 1077–1082. DOI: 10.1212/01.wnl.0000345042.53843.d5. PMID: 19307541.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Nakamura M., Nakazawa T., Doi H. et al. Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica. Graefes Arch Clin Exp Ophthalmol 2010; 248: 1777–1785. DOI: 10.1007/s00417-010-1344-7. PMID: 20300766.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Merle H., Olindo S., Donnio A. et al. Retinal peripapillary nerve fiber layer thickness in neuromyelitis optica. Invest Ophthalmol Vis Sci 2008; 49: 4412–4417. DOI: 10.1167/iovs.08-1815. PMID: 18614811.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Costello F., Coupland S., Hodge W. et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 2006; 59: 963–969. DOI: 10.1002/ana.20851. PMID: 16718705.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Costello F., Hodge W., Pan Y. et al. Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography. Mult Scler 2008; 14: 893–905. DOI: 10.1177/1352458508091367. PMID: 18573837.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Outteryck O., Zephir H., Defoort S. et al. Optical coherence tomography in clinically isolated syndrome: no evidence of subclinical retinal axonal loss. Arch Neurol 2009; 66: 1373–1377. DOI: 10.1001/archneurol.2009.265. PMID: 19901169.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Grazioli E., Zivadinov R., Weinstock-Guttman B. et al. Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis. J Neurol Sci 2008; 268: 12–17. DOI: 10.1016/j.jns.2007.10.020. PMID: 18054962.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Klistorner A., Arvind H., Nguyen T. et al. Axonal loss and myelin in early on loss in postacute optic neuritis. Ann Neurol 2008; 64: 325–331. DOI: 10.1002/ana.21474. PMID: 18825673.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Siger M., Dziegielewski K., Jasek L. et al. Optical coherence tomography inmultiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy. J Neurol 2008; 255: 1555–1560. DOI: 10.1007/s00415-008-0985-5. PMID: 18825432.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Fisher J.B., Jacobs D.A. Markowitz C.E. et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology 2006; 113: 324–332. DOI: 10.1016/j.ophtha.2005.10.040. PMID: 16406539.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Trip S., Schlottmann P., Jones S. et al. Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 2005; 58: 383–391. DOI: 10.1002/ana.20575. PMID: 16075460.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Siepman T., Bettink-Remeijer M., Hintzen R. Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry. J Neurol 2010; 257: 1654–1660. DOI: 10.1007/s00415-010-5589-1. PMID: 20461397.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Khanifar A., Parlitsis G., Ehrlich J. et al. Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography. Clin Ophthalmol 2010; 4: 1007–1013. PMID: 20922034.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Burkholder B., Osborne B. Loguidice M. et al. Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis. Arch Neurol 2009; 66: 1366–1372. DOI: 10.1001/archneurol.2009.230. PMID: 19901168.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Bertuzzi F., Suzani V., Tagliabue E. et al. Diagnostic validity of optic disc and retinal nerve fiber layer evaluations in detecting structural changes after optic neuritis. Ophthalmology 2010; 117: 1256–1264. DOI: 10.1016/j.ophtha.2010.02.024. PMID: 20381872.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Khanifar G., Parlitsis G., Ehrlich J. et al. Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography. Clin Ophthalmol 2010; 4: 1007–1013. PMID: 20922034.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Costello F., Hodge W., Pan Y. et al. Using retinal architecture to help characterize multiple sclerosis patients. Can J Ophthalmol 2010; 45: 520–526. DOI: 10.3129/i10-063. PMID: 20838421.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Gordon-Lipkin E., Chodkowski B., Reich D. et al. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology 2007; 69: 1603–1609. DOI: 10.1212/01.wnl.0000295995.46586.ae. PMID: 17938370.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Frohman E., Dwyer M., Frohman T. et al. Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study. J Neurol Sci 2009; 282: 96–105. DOI: 10.1016/j.jns.2009.04.010. PMID: 19439327.</mixed-citation></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">Eliseeva E.K. [Inflammatory and demyelinating optical neuritis: clinical and functional study. Thesis for a Candidate Degree in Medical Sciences]. Moscow; 2017. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Елисеева Е.К. Оптический неврит воспалительной и демиелинизирующей этиологии клинико-функциональные исследования: дис. … канд. мед. наук. М.; 2017.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Neroev V.V., Eliseeva E.K., Zueva M.V. et al. [Demyelinating optical neuritis: correlation of data of optical coherence tomography and multifocal electroretinography]. Annals of clinical and experimental neurology 2014; 8(2): 22–26. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Нероев В.В., Елисеева Е.К., Зуева М.В. и др. Демиелинизирующий оптический неврит: Корреляция данных оптической когерентной томографии и мультифокальной электроретинографии. Анналы клинической и экспериментальной неврологии 2014; 8(2): 22–26.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">Eliseeva E.K., Neroev V.V., Zueva M.V. et al. [Optical neuritis in multiple sclerosis (literature review and results of author’s research)]. Tochka zreniya. Vostok–Zapad 2018; (2): 112–115. DOI: 10.25276/2410-1257-2018-2-112-115. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Елисеева Е.К., Нероев В.В., Зуева М.В. и др. Оптический неврит на фоне рассеянного склероза (обзор литературы и результаты собственного исследования). Точка зрения. Восток–Запад 2018; (2): 112–115. DOI: 10.25276/2410-1257-2018-2-112-115</mixed-citation></citation-alternatives></ref></ref-list></back></article>
