Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector57810.25692/ACEN.2019.1.6Original articlesОригинальные статьиUnknownIntegrative functions of the retrosplenial cortex in rats: anatomy, connectomics, and cellular electrophysiologyИнтегративные функции ретросплениальной коры: данные анатомии, коннектомики и клеточной электрофизиологии у крысMineevaOlga A.МинееваОльга Александровна
Russian Federation
o.mineyeva@gmail.comBezryadnovDmitrii V.БезрядновДмитрий Васильевич
Russian Federation
o.mineyeva@gmail.comChekhovSergey A.ЧеховСергей Александрович
Russian Federation
o.mineyeva@gmail.comSvarnikОlga E.СварникОльга Евгеньевна
Russian Federation
o.mineyeva@gmail.comAnokhinKonstantin V.АнохинКонстантин Владимирович
Russian Federation
o.mineyeva@gmail.comP.K. Anokhin Institute of Normal PhysiologyФГБНУ «Институт нормальной физиологии им. П.К. Анохина»Moscow Institute of Physics and TechnologyФГАОУ ВО "Московский физико-технический институт"Institute of Psychology of Russian Academy of SciencesФГБУН «Институт психологии РАН»National Research Center "Kurchatov Institute"НИЦ "Курчатовский институт"M.V.Lomonosov Moscow State UniversityФГБОУ ВО "Московский государственный университет им. М.В.Ломоносова"15032019131475417032019Copyright ©; 2019, Mineeva O.A., Bezryadnov D.V., Chekhov S.A., Svarnik О.E., Anokhin K.V.Copyright ©; 2019, Mineeva O.A., Bezryadnov D.V., Chekhov S.A., Svarnik О.E., Anokhin K.V.2019Mineeva O.A., Bezryadnov D.V., Chekhov S.A., Svarnik О.E., Anokhin K.V.Mineeva O.A., Bezryadnov D.V., Chekhov S.A., Svarnik О.E., Anokhin K.V.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/578

Current review is focused on the integrative functions of the retrosplenial cortex, which neurons are largely involved in spatial orientation and ambulation of an organism. We discuss anatomy and connectivity of the retrosplenial cortex in rats as well as the most recent findings concerning the behavioral specialization of its neurons observed using multielectrode recordings. Pattern of connections of the retrosplenial cortex allows to consider its interfacing role in linking brain regions specifically involved in spatial navigation and memory with areas of the associative cortex which lack spatial tuning. In this paper, we touch upon that unique anatomical connectivity which is reflected in the peculiar behavioral specialization of the retrosplenial cortex neurons. Complex spatial tuning of retrosplenial neurons is likely to represent the association of spatial and nonspatial information, and provides a clue to principles of information integration in the cerebral cortex.

Обзор посвящен интегративным функциям ретросплениальной коры, значительная доля нейронов которой обладает специализацией относительно положения и перемещения организма в пространстве. Разбираются современные данные об анатомии и связях ретросплениальной коры у крыс, а также о поведенческой специализации ее нейронов, обнаруженной с помощью мультиэлектродной регистрации клеточной активности. Паттерн связей ретросплениальной коры позволяет рассматривать ее как своеобразное связующее звено между областями мозга, специфически ответственными за пространственную навигацию и ассоциативными областями коры, не имеющими пространственной настройки. Этой уникальной особенностью анатомических связей ретросплениальной коры, по-видимому, объясняется присутствие в ней нейронов не только с пространственными, но и с более сложными поведенческими специализациями, которые рассмотрены в данном обзоре. Подобные сложно специализированные клетки вероятно должны ассоциировать комбинацию пространственной и непространственной информации, и раскрытие механизмов этой ассоциации может принести новое в понимание принципов организации когнитивных функций коры головного мозга.

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