Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector6010.17816/psaic60TechnologiesТехнологииUnknownMicroelectrode recording of neuronal activity in the surgery for Parkinson’s diseaseМикроэлектродная регистрация нейрональной активности в хирургии болезни ПаркинсонаNizametdinovaD. M.НизаметдиноваД. M.
Russian Federation
dinara.dinara@mail.ruTyurnikovVladimir M.ТюрниковВладимир Михайлович
Russian Federation
dinara.dinara@mail.ruFedorenkoI. I.ФедоренкоИ. И.
Russian Federation
dinara.dinara@mail.ruGushchaArtem O.ГущаАртем Олегович
Russian Federation
dinara.dinara@mail.ruhttps://orcid.org/0000-0002-2704-6282IllarioshkinSergey N.ИллариошкинСергей Николаевич
Russian Federation

D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research

д.м.н., проф., член-корр. РАН, зам. директора по научной работе, рук. отдела исследований мозга

dinara.dinara@mail.ruResearch Center of NeurologyФГБНУ «Научный центр неврологии»03062016102424531012017Copyright ©; 2016, Nizametdinova D.M., Tyurnikov V.M., Fedorenko I.I., Gushcha A.O., Illarioshkin S.N.Copyright ©; 2016, Nizametdinova D.M., Tyurnikov V.M., Fedorenko I.I., Gushcha A.O., Illarioshkin S.N.2016Nizametdinova D.M., Tyurnikov V.M., Fedorenko I.I., Gushcha A.O., Illarioshkin S.N.Nizametdinova D.M., Tyurnikov V.M., Fedorenko I.I., Gushcha A.O., Illarioshkin S.N.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/60

Microelectrode recording of neuronal activity is a modern and safe tool for neurophysiological mapping of subcortical brain structures that serve as targets for stereotactic functional neurosurgery. The article discusses the main technical and clinical aspects of this method and focuses on Parkinson’s disease, a classical object of functional neurosurgery. Microelectrode analysis improves the accuracy of electrode positioning and the effectiveness of surgical neuromodulation in Parkinson’s disease, enables investigation of the pathophysiological features of extrapyramidal disorders, mechanisms of action of drugs and various functional neurosurgery techniques, and also facilitates the search for new potential targets for deep brain stimulation.

Микроэлектродная регистрация нейрональной активности – современный и безопасный инструмент нейрофизиологического картирования подкорковых структур головного мозга, служащих мишенями стереотаксической функциональной нейрохирургии. В статье рассматриваются основные технические и клинические аспекты применения данного метода. Микроэлектродный анализ повышает точность позиционирования электрода и эффективность хирургической нейромодуляции при болезни Паркинсона, позволяет изучать патофизиологические особенности экстрапирамидных заболеваний, механизмы действия лекарственных препаратов и различных технологий функциональной нейрохирургии, а также способствует поиску новых потенциальных мишеней для глубокой стимуляции мозга.

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