Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector60410.25692/ACEN.2019.3.6ReviewsОбзорыUnknownThe role of micro-RNA in cerebrovascular diseaseРоль микроРНК в цереброваскулярной патологииRaskurazhevAnton A.РаскуражевАнтон Алексеевич
Russian Federation
rasckey@live.comTanashyanMarine M.ТанашянМаринэ Мовсесовна
Russian Federation
rasckey@live.comResearch Center of NeurologyФГБНУ «Научный центр неврологии»06082019133414601092019Copyright ©; 2019, Raskurazhev A.A., Tanashyan M.M.Copyright ©; 2019, Raskurazhev A.A., Tanashyan M.M.2019Raskurazhev A.A., Tanashyan M.M.Raskurazhev A.A., Tanashyan M.M.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/604

The article touches upon micro-RNA as new, potentially significant diagnostic, prognostic and therapeutic biomarkers in cerebrovascular pathology. Synthesis processes and effector mechanisms of micro-RNA are described. The micro-RNA that play an important role in the pathogenesis of major risk factors for cerebrovascular pathology (atherosclerosis, arterial hypertension, atrial fibrillation, diabetes mellitus) and the micro-RNA in acute cerebrovascular disorders are reviewed in detail. The need for thorough replication studies to justify the choice of micro-RNA and methods for micro-RNA detection is substantiated.

В обзоре рассматриваются микроРНК как новые, потенциально значимые диагностические, прогностические и терапевтические биомаркеры при цереброваскулярной патологии. Описаны процессы синтеза и эффекторные механизмы микроРНК. Подробно рассмотрены микроРНК, играющие важную роль в патогенезе основных состояний — факторов риска сосудистой патологии головного мозга (атеросклероза, артериальной гипертонии, фибрилляции предсердий, сахарного диабета), и микроРНК при острых нарушениях мозгового кровообращения. Доказана необходимость проведения тщательных репликативных исследований, детально обосновывающих выбор и методики определения микроРНК.

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