Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector6710.17816/psaic67ReviewsОбзорыUnknownA role of genetic factors in the development of individual predisposition to ischemic strokeРоль генетических факторов в формировании индивидуальной предрасположенности к ишемическому инсультуKorchaginV. I.КорчагинВиталий Иванович
Russian Federation
vitaly_korchagin@rambler.ruMironovK. O.МироновK. O.
Russian Federation
vitaly_korchagin@rambler.ruDribnokhodovaO. P.ДрибноходоваO. П.
Russian Federation
vitaly_korchagin@rambler.ruhttps://orcid.org/0000-0002-7682-6672MaksimovaMarina Yu.МаксимоваМарина Юрьевна
Russian Federation
vitaly_korchagin@rambler.ruhttps://orcid.org/0000-0002-2704-6282IllarioshkinSergey N.ИллариошкинСергей Николаевич
Russian Federation

D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research

д.м.н., проф., член-корр. РАН, зам. директора по научной работе, рук. отдела исследований мозга

vitaly_korchagin@rambler.ruhttps://orcid.org/0000-0002-5883-8119TanashyanMarine M.ТанашянМаринэ Мовсесовна
Russian Federation

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

д.м.н., профессор, член-корреспондент РАН, зам. директора по научной работе, рук. 1-го неврологического отделения

vitaly_korchagin@rambler.ruPlatonovA. E.ПлатоновA. И.
Russian Federation
vitaly_korchagin@rambler.ruShipulinG. A.ШипулинГ. A.
Russian Federation
vitaly_korchagin@rambler.ruhttps://orcid.org/0000-0003-0522-767XRaskurazhevAnton A.РаскуражевАнтон Алексеевич
Russian Federation

Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department

к.м.н., врач-невролог, с.н.с. 1-го неврологического отделения

vitaly_korchagin@rambler.ruhttps://orcid.org/0000-0002-6338-0392PiradovMikhail A.ПирадовМихаил Александрович
Russian Federation

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

д.м.н., проф., академик РАН, директор

vitaly_korchagin@rambler.ruCentral Research Institute of EpidemiologyФБУН «Центральный НИИ эпидемиологии» РоспотребнадзораResearch Center of Neurology, MoscowФГБНУ «Научный центр неврологии»Research Center of NeurologyФГБНУ «Научный центр неврологии»03032016101657531012017Copyright ©; 2016, Korchagin V.I., Mironov K.O., Dribnokhodova O.P., Maxsimova M.Y., Illarioshkin S.N., Tanashyn M.M., Platonov A.E., Shipulin G.A., Raskurazhev A.A., Piradov M.A.Copyright ©; 2016, Korchagin V.I., Mironov K.O., Dribnokhodova O.P., Maxsimova M.Y., Illarioshkin S.N., Tanashyn M.M., Platonov A.E., Shipulin G.A., Raskurazhev A.A., Piradov M.A.2016Korchagin V.I., Mironov K.O., Dribnokhodova O.P., Maxsimova M.Y., Illarioshkin S.N., Tanashyn M.M., Platonov A.E., Shipulin G.A., Raskurazhev A.A., Piradov M.A.Korchagin V.I., Mironov K.O., Dribnokhodova O.P., Maxsimova M.Y., Illarioshkin S.N., Tanashyn M.M., Platonov A.E., Shipulin G.A., Raskurazhev A.A., Piradov M.A.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/67

Intensive development of DNA analysis technologies and largescale genome-wide association studies have led to accumulation of a large array of data on the relationship between genetic factors and various phenotypic manifestations, including monogenic and polygenic hereditary diseases. This greatly has extended the capabilities of clinical diagnostics and predictive medicine in the field of socially significant diseases. For example, a role of a genetic component of the risk for such a multifactorial and polyetiologic disease as stroke is now actively explored. Large-scale studies have revealed both general and specific genetic markers associated only with a certain type and subtype of stroke. This review analyzes the current state of the problem of using genetic markers for diagnosis of stroke predisposition, complex issues associated with multiplicity of risk factors for stroke, and possible development in this area.

Интенсивное развитие технологий анализа ДНК и масштабные исследования полногеномных ассоциаций привели к накоплению большого массива данных о связи генетических факторов с различными фенотипическими проявлениями, в т.ч. с моногенными и полигенными наследственными заболеваниями. Благодаря этому значительно расширились возможности клинической диагностики и предиктивной медицины в области социально значимых заболеваний. Так, в настоящее время активно развиваются исследования генетического компонента в формировании риска развития такого многофакторного и полиэтиологического заболевания, как инсульт. В крупномасштабных исследованиях выявлены как общие, так и специфические генетические маркеры, ассоциированные только с инсультом определенного типа и подтипа. В настоящем обзоре проведен анализ современного состояния проблемы использования генетических маркеров для диагностики предрасположенности к инсульту, сложных вопросов, связанных с множественностью факторов риска инсульта, а также возможных путей развития данного направления.

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