Annals of Clinical and Experimental NeurologyAnnals of Clinical and Experimental NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-2533Eco-Vector70610.25692/ACEN.2020.4.13Clinical analysisКлинический разборUnknownSurgical treatment of epilepsy secondary to a hypothalamic hamartoma: a case reportХирургическое лечение эпилепсии на фоне гамартомы гипоталамуса: клинический случайAreshkinaIrina G.АрешкинаИрина Геннадьевна
Russian Federation
strotskaya1992@mail.ruDmitrenkoDiana V.ДмитренкоДиана Викторовна
Russian Federation
strotskaya1992@mail.ruDmitrenkoAlexey I.ДмитренкоАлексей Иванович
Russian Federation
strotskaya1992@mail.ruNarodovaEkaterina A.НародоваЕкатерина Андреевна
Russian Federation
strotskaya1992@mail.ruProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого»Krasnoyarsk Interdistrict Clinical Emergency Hospital named after N.S. Karpovich2КГБУЗ «Красноярская межрайонная клиническая больница скорой медицинской помощи им. Н.С. Карповича»261220201449610226122020Copyright ©; 2020, Areshkina I.G., Dmitrenko D.V., Dmitrenko A.V., Narodova E.A.Copyright ©; 2020, Areshkina I.G., Dmitrenko D.V., Dmitrenko A.V., Narodova E.A.2020Areshkina I.G., Dmitrenko D.V., Dmitrenko A.V., Narodova E.A.Areshkina I.G., Dmitrenko D.V., Dmitrenko A.V., Narodova E.A.https://creativecommons.org/licenses/by/4.0https://annaly-nevrologii.com/pathID/article/view/706

A hypothalamic hamartoma is a benign, congenital, heterotopic, neoplastic space-occupying mass located in the interpeduncular fossa, corresponding to a gangliocytoma according to the morphological classification. Patients with hypothalamic hamartoma often experience gelastic seizures and early puberty. Increasing evidence that hypothalamic hamartomas are the cause of gelastic seizures and secondary epileptogenesis has led to surgery being used more often as a permanent cure. Several minimally invasive procedures have been developed, including neuroendoscopic approaches and various stereotactic techniques in radiofrequency and laser ablation. Each method can lead to its own unique side effects. We conducted a review of the available Russian and international literature. This case report describes the surgical treatment of epilepsy secondary to a hypothalamic hamartoma.

Гамартома гипоталамуса — это врожденное, объемное гетеротопное неопластическое образование межножковой ямки, доброкачественного характера, по морфологической классификации соответствует ганглиоцитомам. У пациентов с гамартомой гипоталамуса нередко наблюдаются геластические приступы и раннее половое созревание. Увеличивающиеся доказательства, подтверждающие роль гипоталамических гамартом как причины геластических приступов и вторичного эпилептогенеза, привели к более частому использованию хирургии в качестве окончательного лечения. Разработано несколько минимально инвазивных процедур, включая нейроэндоскопические подходы и различные стереотаксические методы радио- и лазерной абляции. Каждый из этих методов может привести к уникальным побочным эффектам. Проведен обзор доступных источников отечественной и зарубежной литературы. Представлено описание клинического случая хирургического лечения эпилепсии на фоне гамартомы гипоталамуса.

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