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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">729</article-id><article-id pub-id-type="doi">10.25692/ACEN.2021.1.9</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Comparing the results of surgical and conservative treatment of patients with supratentorial hypertensive intracerebral hemorrhage. A new look at previously known randomized studies</article-title><trans-title-group xml:lang="ru"><trans-title>Сравнение результатов хирургического и консервативного лечения больных с супратенториальными гипертензивными внутримозговыми гематомами. Новый взгляд на известные ранее рандомизированные исследования</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Godkov</surname><given-names>Ivan M.</given-names></name><name xml:lang="ru"><surname>Годков</surname><given-names>Иван Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v485@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dashyan</surname><given-names>Vladimir G.</given-names></name><name xml:lang="ru"><surname>Дашьян</surname><given-names>Владимир Григорьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v485@bk.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine</institution></aff><aff><institution xml:lang="ru">ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.V. Sklifosovsky Research Institute for Emergency Medicine</institution></aff><aff><institution xml:lang="ru">ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского», Москва</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-03-24" publication-format="electronic"><day>24</day><month>03</month><year>2021</year></pub-date><volume>15</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>71</fpage><lpage>79</lpage><history><date date-type="received" iso-8601-date="2021-03-24"><day>24</day><month>03</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Godkov I.M., Dashyan V.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Godkov I.M., Dashyan V.G.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Godkov I.M., Dashyan V.G.</copyright-holder><copyright-holder xml:lang="ru">Godkov I.M., Dashyan V.G.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/729">https://annaly-nevrologii.com/pathID/article/view/729</self-uri><abstract xml:lang="en"><p>Hemorrhagic stroke is a medical and social problem, with an incidence of 15–35 per 100 000 people per year. It is characterized by high patient mortality (up to 53% in the first year) and disability, with most of the surviving patients having persistent neurological deficits and about 20% of them requiring continuous assistance.</p> <p>The advantages of surgical or conservative treatment of patients with supratentorial hypertensive intracerebral hemorrhage (ICH) are still under discussion. This literature review is based on 12 open-source articles on prospective randomized trials comparing conservative and surgical treatment results in patients with supratentorial ICH, which demonstrate contradictory results.</p> <p>Based on an analysis of all the works, we can conclude that surgical treatment has an advantage when performed early (within 12–72 hours) in patients whose level of consciousness is 9–12 points on the Glasgow Coma Scale. Needle aspiration and local fibrinolysis are effective for basal ganglia ICH, while open surgery and endoscopic aspiration are effective in subcortical ICH. For subcortical ICHs that are 20–80 cm<sup>3</sup> in size, surgical treatment improved functional outcomes, while in ICHs larger than 50 cm<sup>3</sup>, it helped to reduce mortality.</p></abstract><trans-abstract xml:lang="ru"><p>Геморрагический инсульт является медицинской и социальной проблемой — частота случаев составляет 15–35 на 100 тыс. населения в год. Он характеризуется высокой летальностью (до 53% в течение первого года) и инвалидизацией больных: большинство выживших пациентов имеют стойкие неврологические расстройства, а около 20% из них нуждаются в постоянной посторонней помощи.</p> <p>Преимущества хирургического или консервативного лечения больных с гипертензивными внутримозговыми гематомами (ВМГ) супратенториальной локализации являются предметом дискуссии. Данный обзор литературы выполнен на основании 12 доступных в открытых источниках работ проспективных рандомизированных исследований, посвященных сравнению результатов консервативного и хирургического лечения больных с супратенториальными ВМГ, которые продемонстрировали противоречивые результаты.</p> <p>По результатам анализа всех работ можно сделать выводы о том, что хирургическое лечение имеет преимущество при выполнении операции в ранние сроки (в течение 12–72 ч) у больных с уровнем бодрствования 9–12 баллов по шкале комы Глазго. Пункционная аспирация и локальный фибринолиз эффективны при ВМГ базальных ядер, открытая хирургия и эндоскопическая аспирация — при ВМГ субкортикальной локализации. При субкортикальных ВМГ объемом 20–80 см<sup>3</sup> хирургическое лечение позволяло улучшить функциональные исходы, при ВМГ более 50 см<sup>3</sup> — способствовало уменьшению летальности.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hemorrhagic stroke</kwd><kwd>supratentorial intracerebral hemorrhage prospective studies</kwd><kwd>randomized studies</kwd><kwd>surgical treatment</kwd><kwd>conservative treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>геморрагический инсульт</kwd><kwd>супратенториальные внутримозговые гематомы</kwd><kwd>проспективные исследования</kwd><kwd>рандомизированные исследования</kwd><kwd>хирургическое лечение</kwd><kwd>консервативное лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Krylov V.V., Dashyan V.G., Burov S.A., Petrikov S.S. Surgery of hemorrhagic stroke. Moscow, 2012. 336 p. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Крылов В.В., Дашьян В.Г., Буров С.А., Петриков С.С. Хирургия геморрагического инсульта. М., 2012. 336 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Schmidek H.H., Roberts D.W. (eds.) Schmidek&amp;Sweet Neurosurgical Techniques: indications, methods, and results. Philadelphia, 2005.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Franke C.L., van Swieten J.C., Algra A., van Gjin J. Prognostic factors in patients with intracerebral hematoma. J Neurol Neurosurg Psychiatry. 1992; 55: 653–657. DOI: 10.1136/jnnp.55.8.653. PMID: 1527534.</mixed-citation></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Koltover A.N., Vereschagin N.V., Lyudkovskaya I.G., Morgunov V.A. Pathologic anatomy of cerebrovascular diseases.Moscow, 1975. 256 p. (in Russ.)</mixed-citation><mixed-citation xml:lang="ru">Колтовер А.Н., Верещагин Н.В., Людковская И.Г., Моргунов В.А. Патологическая анатомия нарушений мозгового кровообращения. М., 1975. 256 с.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><mixed-citation>Lee K.R., Colon G.P., Betz A.L. et al. Edema from intracerebral hemorrhage: the role of thrombin. J Neurosurg. 1996; 84: 91–96. DOI: 10.3171/jns.1996.84.1.0091. PMID: 8613842.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Lee K.R., Kawai N., Kim S. et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model. J Neurosurg. 1997; 86: 272–278. DOI: 10.3171/jns.1997.86.2.0272. PMID: 9010429.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Broderick J., Connolly S., Feldmann E. et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: A guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Circulation. 2007; 116(16): e391–e413. DOI: 10.1161/CIRCULATIONAHA.107.183689. PMID: 17938297.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kaneko M., Tanaka K., Shimada T. et al. Long-term evaluation of ultra-early operation for hypertensive intracerebral hemorrhage in 100 cases. J. Neurosurg. 1983; 58: 838–842. DOI: 10.3171/jns.1983.58.6.0838. PMID: 6854376.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Broderick J.P., Brott T.G., Duldner J.E. et al. Volume of intracerebral hemorrhage. A powerful and easy to use predictor of 30-day mortality. Stroke. 1993; 24(7): 987–993. DOI: 10.1161/01.str.24.7.987. PMID: 8322400.</mixed-citation></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Dashyan V.G. [Surgery of hemorrhagic stroke. Abstract med. sci. diss.]. Moscow, 2009. 49 p. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Дашьян В.Г. Хирургическое лечение геморрагического инсульта: автореф. дис. ... докт. мед. наук. М., 2009. 49 с.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><mixed-citation>Cho D.Y., Chen C.C., Chang C.S. et al. Endoscopic surgery for spontaneous basal ganglia hemorrhage: comparing endoscopic surgery, stereotactic aspiration, and craniotomy in noncomatose patients. Surg Neurol. 2006; 65: 547–555. DOI: 10.1016/j.surneu.2005.09.032. PMID: 16720167.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Nishihara T., Morita A., Teraoka A., Kirino T. Endoscopy-guided removal of spontaneous intracerebral hemorrhage: comparison with computer tomography-guided stereotactic evacuation. Childs Nerv Syst. 2007; 23(6): 677–683. DOI: 10.1007/s00381-007-0325-6. PMID: 17468874.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>McKissock W., Richardson A., Taylor J. Primary intracerebral haemorrhage: a controlled trial of surgical and conservative treatment in 180 unselected cases. Lancet. 1961; 2: 221–226.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Juvela S., Heiskanen O., Poranen A. et al. The treatment of spontaneous intracerebral hemorrhage. A prospective randomised trial of surgical and conservative treatment. J Neurosurg. 1989; 70(5): 755–758. DOI: 10.3171/jns.1989.70.5.0755. PMID: 2651586.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Morgenstern L.B., Frankowski R.F., Shedden P. et al. Surgical treatment for intracerebral hemorrhage (STICH): a single-center, randomized clinical trial. Neurology. 1998; 51: 1359–1363. DOI: 10.1212/wnl.51.5.1359. PMID: 9818860.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Auer L.M., Deinsberger W., Neiderkorn K. et al. Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma: a randomized study. J. Neurosurg. 1989; 70: 530–535. DOI: 10.3171/jns.1989.70.4.0530. PMID: 2926492.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Pantazis G., Tsitsopoulos P., Mihas C. et al. Early surgical treatment vs conservative management for spontaneous supratentorial intracerebral hematomas: A prospective randomized study. Surg Neurol. 2006; 66: 492–501. DOI: 10.1016/j.surneu.2006.05.054. PMID: 17084196.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Hattori N., Katayama Y., Maya Y., Gatherer A. Impact of stereotactic hematoma evacuation on activities of daily living during the chronic period following spontaneous putaminal hemorrhage: a randomized study. J Neurosurg. 2004; 101: 417–420. DOI: 10.3171/jns.2004.101.3.0417. PMID: 15352598.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Wang W.Z., Jiang B., Liu H.M. et al. Minimally invasive craniopuncture therapy vs. conservative treatment for spontaneous intracerebral hemorrhage: results from a randomized clinical trial in China. Int J Stroke. 2009; 4: 11–16. DOI: 10.1111/j.1747-4949.2009.00239.x. PMID: 19236490.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Mendelow A.D., Gregson B.A., Rowan E.N. et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet. 2013; 382(9890): 397–408. Erratum in: Lancet. 2013; 382(9890): 396. DOI: 10.1016/S0140-6736(13)60986-1. PMID: 23726393.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Batjer H., Reisch J., Allen B. et al. Failure of surgery to improve outcome in hypertensive putaminal hemorrhage. A prospective randomised trial. Arch Neurol. 1990; 47(10): 1103–6. DOI: 10.1001/archneur.1990.00530100071015. PMID: 2222242.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Mendelow A.D., Gregson B.A., Fernandes H.M. et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet. 2005; 365(9457): 387–397. DOI: 10.1016/S0140-6736(05)17826-X. PMID: 15680453.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Zuccarello M., Brott T., Derex L. et al. Early surgical treatment for intracerebral hemorrage. A randomized feasibility study. Stroke. 1999; 30: 1833–1839. DOI: 10.1161/01.str.30.9.1833. PMID: 10471432.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Teernstra O.P.M., Evers S.M.A.A., Lodder J. et al. Stereotactic treatment of intracerebral hematoma by means of a plasminogen activator: a multicenter randomized controlled trial (SICHPA). Stroke. 2003; 34: 968–974. DOI: 10.1161/01.STR.0000063367.52044.40. PMID: 12649510.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Teasdale G., Jennett B. Assessment of coma and impaired consciousness: A practical scale. Lancet. 1974; 2: 81–84. DOI: 10.1016/s0140-6736(74)91639-0. PMID: 4136544.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Jennett B., Bond M. Assessment of outcome after severe brain damage. Lancet. 1975; 1(7905): 480–484. DOI: 10.1016/s0140-6736(75)92830-5. PMID: 46957.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Kanaya H., Yukawa H., Ito Z. et al. Grading and indications for treatment of ICH of basal ganglia (cooperative study in Japan). In: H.W. Pia, C. Langmaid, J. Zierski (eds.) Spontaneous Intracerebral Hematomas: Advances in Diagnosis and Therapy. Berlin, 1980: 268–274.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Starke R.M., Komotar R.J., Connolly E.S. A randomized clinical trial and meta-analysis of early surgery vs. initial conservative treatment in patients with spontaneous lobar intracerebral hemorrhage. Neurosurgery. 2014; 74(2): N11–N12. DOI: 10.1227/01.neu.0000442974.53712.26. PMID: 24435143.</mixed-citation></ref></ref-list></back></article>
