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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Annals of Clinical and Experimental Neurology</journal-id><journal-title-group><journal-title xml:lang="en">Annals of Clinical and Experimental Neurology</journal-title><trans-title-group xml:lang="ru"><trans-title>Анналы клинической и экспериментальной неврологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-5473</issn><issn publication-format="electronic">2409-2533</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">745</article-id><article-id pub-id-type="doi">10.25692/ACEN.2021.2.5</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The effect of education level on functional brain organization in patients with chronic cerebral ischemia</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние уровня образования на функциональную организацию мозга больных хронической церебральной ишемией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fokin</surname><given-names>Vitaly F.</given-names></name><name xml:lang="ru"><surname>Фокин</surname><given-names>Виталий Федорович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ponomareva</surname><given-names>Natalia V.</given-names></name><name xml:lang="ru"><surname>Пономарева</surname><given-names>Наталия Васильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Konovalov</surname><given-names>Rodion N.</given-names></name><name xml:lang="ru"><surname>Коновалов</surname><given-names>Родион Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Krotenkova</surname><given-names>Marina V.</given-names></name><name xml:lang="ru"><surname>Кротенкова</surname><given-names>Марина Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Medvedev</surname><given-names>Roman B.</given-names></name><name xml:lang="ru"><surname>Медведев</surname><given-names>Роман Борисович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lagoda</surname><given-names>Olga V.</given-names></name><name xml:lang="ru"><surname>Лагода</surname><given-names>Ольга Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tanashyan</surname><given-names>Marine M.</given-names></name><name xml:lang="ru"><surname>Танашян</surname><given-names>Маринэ Мовсесовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fvf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Center of Neurology</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Научный центр неврологии»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-06-17" publication-format="electronic"><day>17</day><month>06</month><year>2021</year></pub-date><volume>15</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>35</fpage><lpage>41</lpage><history><date date-type="received" iso-8601-date="2021-06-16"><day>16</day><month>06</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Fokin V.F., Ponomareva N.V., Konovalov R.N., Krotenkova M.V., Medvedev R.B., Lagoda O.V., Tanashyan M.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Fokin V.F., Ponomareva N.V., Konovalov R.N., Krotenkova M.V., Medvedev R.B., Lagoda O.V., Tanashyan M.M.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Fokin V.F., Ponomareva N.V., Konovalov R.N., Krotenkova M.V., Medvedev R.B., Lagoda O.V., Tanashyan M.M.</copyright-holder><copyright-holder xml:lang="ru">Fokin V.F., Ponomareva N.V., Konovalov R.N., Krotenkova M.V., Medvedev R.B., Lagoda O.V., Tanashyan M.M.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://annaly-nevrologii.com/pathID/article/view/745">https://annaly-nevrologii.com/pathID/article/view/745</self-uri><abstract xml:lang="en"><p>The level of education is an important factor that prevents cognitive decline in normal and pathological aging, including in neurodegenerative and vascular diseases.</p> <p><bold>This study aimed</bold> to examine cerebral connectivity in patients with tertiary and secondary education suffering from chronic cerebral ischemia.</p> <p><bold>Materials and methods.</bold> We examined 54 patients (mean age 64.4 years) with chronic cerebrovascular disease who had completed either tertiary or secondary education. The Luria test was used to assess short-term memory, while the connectome organization was studied using resting-state functional magnetic resonance imaging.</p> <p><bold>Results. </bold>On average, patients with tertiary education recalled 35.0 ± 1.1 words out of a possible 50, while patients with secondary education only recalled 31.1 ± 1.2 words (<italic>p</italic> = 0.018). Patients with higher education had a higher number of interhemispheric connections in the connectome than the group without higher education. In patients without tertiary education, predominate the intrahemispheric connections in the right hemisphere. We hypothesize that this connectome organization provides a cognitive advantage in people with higher education, compared to patients without higher education.</p></abstract><trans-abstract xml:lang="ru"><p>Длительность образования является одним из важных факторов, препятствующих когнитивному снижению при нормальном и патологическом старении, включая нейродегенеративные и сосудистые заболевания.</p> <p><bold>Цель</bold> работы — исследование особенностей церебральной коннективности у пациентов с высшим и средним образованием, страдающих хронической ишемией мозга.</p> <p><bold>Материалы и методы.</bold> Обследовали 54 пациентов (средний возраст 64,4 года) с высшим и средним образованием с хроническими цереброваскулярными заболеваниями. Кратковременную память тестировали по Лурия (тест вербальной памяти), организацию коннектома изучали с помощью функциональной магнитно-резонансной томографии покоя.</p> <p><bold>Результаты. </bold>Больные с высшим образованием в среднем воспроизводили 35,0 ± 1,1 слова из 50 возможных, а пациенты со средним образованием — 31,1 ± 1,2 (<italic>р</italic> = 0,018). У больных с высшим образованием в коннектоме имелось большое число межполушарных связей по сравнению с группой без высшего образования. Преобладающая организация коннективности у пациентов без высшего образования — это внутриполушарные связи правого полушария. У больных с высшим образованием в коннектоме имелось большое число межполушарных связей по сравнению с группой без высшего образования.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic cerebral ischemia</kwd><kwd>level of education</kwd><kwd>resting-state functional magnetic resonance imaging</kwd><kwd>connectome</kwd><kwd>interhemispheric connections</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хроническая ишемия мозга</kwd><kwd>длительность образования</kwd><kwd>функциональная магнитно-резонансная томография покоя</kwd><kwd>коннектом</kwd><kwd>межполушарные отношения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Suslina Z.A., Illarioshkin S.N., Piradov M.A. Neurology and neuroscience — development prognosis. Annals of Clinical and Experimental Neurology. 2007; 1(1): 5–9. 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